Divie Bethune McCartee (Simplified Chinese: 麦嘉缔) (1820–1900) was an American Protestant Christian medical missionary, educator and U.S. diplomat in China and Japan, first appointed by the American Presbyterian Mission in 1843.

In 1845, he organized the first Protestant church on Chinese soil. He later served as United States Consul at Ningbo, China and was also judge of the "mixed court" at Shanghai. His career in Japan led him to be a professor in the Imperial University at Tokyo, and he was also Secretary of the Chinese legation there. His prolific writings covered Asiatic history, linguistics, natural science, medicine and politics in the publications of the American Geographical Society, the American Oriental Society and other associations.

Divie Bethune McCartee was born in Philadelphia on January 13, 1820, the oldest son of Dr. Robert McCartee of New York. He entered Columbia University, New York City, at the age of 14 and graduated from the University of Pennsylvania Medical School at 20. In June 1843, while engaged in the practice of medicine in Philadelphia, he received a message from the Board of Foreign Missions of the Church that he was needed to go to China as a pioneer and medical missionary. After consulting with members of his family, he agreed to go.

McCartee sailed for China in 1843 and arrived in Ningbo, Zhejiang, China in 1844. He began working primarily in medicine and evangelism. He was likely the first Protestant missionary, and certainly the first physician, to reside on Chinese soil following the First Opium War. He soon mastered the Chinese language, and his linguistic skills would be put to a variety of future uses. He opened a mission at Ningbo, one of the five ports opened to foreign trade and intercourse by the Treaty of Nanking in 1842.

In 1845, he organized the first Protestant church on Chinese soil. It was there that he married fellow missionary, Juana M. Knight in 1853. She was the first single Presbyterian woman to travel to China.

In 1868 or 1869, the McCartees adopted Kin Yamei (1864–1934), the daughter of Christian colleagues who died from disease when she was two years old. She became the first Chinese woman doctor educated abroad.

In addition to his medical work, he became an adviser and interpreter for American officials and was later vice-consul in Chefoo (present-day Yantai) and Shanghai. McCartee acted in place of an American Consul until a regular consular service was set up in 1857. In this capacity in May 1861, at the request of United States Flag-Officer Stribling, he entered Nanjing, across the battle lines and helped persuade the "Heavenly King", Hong Xiuquan of the Taipings to promise "non-molestation not only to Americans and Christians, but to all Chinese in their employ." By this effort large numbers of native Christians and their friends were rescued when the Taiping army entered Ningbo.

In 1862, he was appointed vice-consul to Japan and became one of the first Protestant missionaries to work there. His tract translated into Japanese was the first Protestant literature in Japan.