Don: The Chase Begins Again is a 2006 Indian Hindi-language action thriller film directed by Farhan Akhtar, who co-wrote the screenplay with his father, Javed Akhtar. Produced by Ritesh Sidhwani and Farhan Akhtar under Excel Entertainment, the film stars Shah Rukh Khan in a dual role as the titular criminal and his look-alike Vijay, alongside Priyanka Chopra as Roma. The supporting cast includes Arjun Rampal, Isha Koppikar, Boman Irani, Om Puri, and Pavan Malhotra, with Kareena Kapoor appearing in a special appearance. A remake of the 1978 film Don, the story follows a man recruited by the police to impersonate a wounded drug lord and infiltrate his criminal organization.

Conceived as both a remake and homage to the original film and the 1970s era of Hindi cinema, the project was envisioned by Akhtar with a modern, international treatment. The director retained the core plot while introducing new elements. Principal photography took place in Mumbai and extensively in Malaysia, which served as the backdrop for over 80% of the film. The soundtrack was composed by Shankar–Ehsaan–Loy, with lyrics by Javed Akhtar, and features both original tracks and updated versions of iconic songs from the 1978 film.

Don was released theatrically on 20 October 2006 during the Diwali festival, clashing with Jaan-E-Mann. It received positive reviews from critics, who praised its stylized action sequences, production design, soundtrack, cinematography, and the performances of Khan and Chopra. The film grossed over ₹1.06 billion worldwide against a budget of ₹400 million, becoming the fifth highest-grossing Hindi film of the year. The film's twist ending was particularly well-received, allowing the remake to be seen as a standalone narrative rather than a mere retelling.

Don won the Best Asian Film award at the Neuchâtel International Fantastic Film Festival and earned nine nominations at the 52nd Filmfare Awards, including Best Film and Best Actor (Khan). A sequel, Don 2, was released on 23 December 2011.

In Kuala Lumpur, Malaysia, the Asian illegal drug trade is thriving under the leadership of Singhania, one of two lieutenants of the late drug kingpin Boris. Singhania’s network is managed by his trusted associate Don, a powerful and elusive criminal. Deputy Commissioner of Police D'Silva leads a special task force targeting the cartel. His objective is to capture Don and dismantle the organization. Don, however, remains untouchable and ruthless, murdering Ramesh, a gang member who attempts to exit the business. Ramesh's fiancée, Kamini, tries to help the police trap Don but is also killed. Roma, Ramesh’s sister, joins Don’s gang to avenge her brother and Kamini’s deaths.

During a failed police operation, Don is severely injured and falls into a coma. Seeing an opportunity, D'Silva recruits Vijay, a lookalike of Don and a simpleton from Mumbai who makes a living performing stunts. D'Silva trains Vijay to impersonate Don and infiltrate the gang, promising to arrange schooling for Deepu, a child Vijay cares for. Meanwhile, Jasjit, Deepu’s estranged father and a former IT professional, is released from prison. Years earlier, Jasjit was coerced into stealing diamonds to save his kidnapped wife but was caught by D'Silva, who did not believe his story. Jasjit's wife died during the ordeal, and he now seeks revenge.

In the hospital, Vijay undergoes surgery to match Don’s appearance. When Don dies from cardiac arrest, Vijay assumes his identity and re-enters the criminal world. D'Silva assigns Vijay to recover a disc containing details of the cartel’s operations. During this mission, Roma attempts to kill him, but D'Silva intervenes and reveals Vijay’s true identity. Vijay retrieves the disc and hands it to D'Silva, who later kills Singhania in a nightclub raid. During the shootout, D'Silva is fatally wounded, leaving Vijay without anyone to confirm his real identity. Arrested and disavowed by Don’s associates, Vijay escapes during a prisoner transport and seeks out Roma to prove his innocence.

Jasjit, meanwhile, finds the disc in D'Silva’s apartment but is forced to exchange it for Deepu’s life when he is contacted by the boy’s captors. He discovers that D'Silva is alive and is actually Vardhaan—the second of Boris’s lieutenants, long believed to be missing. Vardhaan had orchestrated the entire plan, using Vijay to eliminate Singhania and gain control of the cartel. Jasjit rescues Deepu and joins forces with Vijay and Roma. Together, they inform Interpol, and Vardhaan is arrested after a confrontation with Vijay.