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Donald E. Ingber
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Donald E. Ingber
Donald E. Ingber (born 1956)[citation needed] is an American cell biologist and bioengineer. He is the founding director of the Wyss Institute for Biologically Inspired Engineering at Harvard University, the Judah Folkman Professor of Vascular Biology at Harvard Medical School and Boston Children's Hospital, and Professor of Bioengineering at the Harvard John A. Paulson School of Engineering and Applied Sciences. He is also a member of the American Institute for Medical and Biological Engineering, the National Academy of Engineering, the National Academy of Medicine, the National Academy of Inventors, and the American Academy of Arts and Sciences.
Ingber is a founder of the emerging fields of biologically inspired engineering. He has made pioneering contributions to numerous other disciplines including mechanobiology, cytoskeletal biology, extracellular matrix biology, integrin signaling, tumor angiogenesis, tissue engineering, nanobiotechnology, systems biology, and translational medicine. Ingber has authored more than 470 publications in scientific journals and books, and is an inventor on more than 190 patents spanning anti-cancer therapeutics, tissue engineering, medical devices, drug delivery systems, biomimetic materials, nanotherapeutics, and bioinformatics software.
Ingber has been scientific founder of five companies: Neomorphics, Inc., a tissue engineering startup which led to clinical products through subsequent acquisitions (Advanced Tissue Sciences Inc.); Tensegra, Inc. (formerly known as Molecular Geodesics, Inc.,) which 3D-printed medical devices; and most recently, Emulate, Inc., which formed to commercialize human "organs-on-chips" that accelerate drug development, detect toxicities and advance personalized medicine by replacing animal testing; Boa Biomedical, Inc. (originally known as Opsonix, Inc.), which aims to reduce deaths due to sepsis and blood infections by removing pathogens from the blood; and FreeFlow Medical Devices, LLC, which develops special coatings for medical devices to eliminate the formation of blood clots and biofilms on materials.
Ingber grew up in East Meadow, New York. He received a combined B.A./M.A. in molecular biophysics and biochemistry from Yale College and Yale Graduate School of Arts and Sciences in 1977; an M.Phil. in cell biology from Yale Graduate School of Arts and Sciences in 1981; and a combined M.D./Ph.D. from Yale School of Medicine and Yale Graduate School of Arts and Sciences in 1984.[citation needed] At Yale, he carried out undergraduate research on DNA repair with Paul Howard-Flanders, and on cancer metastasis with Alan Sartorelli.
Ingber worked on development of cancer therapeutics[citation needed] with Kenneth Harrap at the Royal Cancer Hospital/Royal Marsden Hospital in England, with support from a Bates Traveling Fellowship. He carried out his Ph.D. dissertation research under the direction of Dr. James Jamieson in the department of cell biology, and his advisory committee included George Palade, Elizabeth Hay and Joseph Madri. From 1984 to 1986 he completed his training as an Anna Fuller Postdoctoral Fellow under the mentorship of Dr. Judah Folkman in the Surgical Research Laboratory at Boston Children's Hospital and Harvard Medical School.
Ingber is best known for his discovery of the role mechanical forces play in developmental control and in cancer formation, and for his application of these principles to develop bioinspired medical devices, nanotechnologies, and therapeutics. Ingber's early scientific work led to the discovery that tensegrity architecture - first described by the architect Buckminster Fuller and the sculptor Kenneth Snelson - is a fundamental design principle that governs how living systems are structured, from individual molecules and cells to whole tissues, organs and organisms.
Ingber's work on tensegrity led him to propose that mechanical forces play as important a role in biological control as chemicals and genes do, and to investigate the molecular mechanism by which cells convert mechanical signals into changes in intracellular biochemistry and gene expression, a process known as "mechanotransduction." Ingber determined that living cells use tensegrity architecture to stabilize their shape and cytoskeleton, that cellular integrins function as mechanosensors on the cell surface, and that cytoskeletal tension (or "prestress," which is central to the stability of tensegrity structures) is a fundamental regulator of many cellular responses to mechanical cues. Ingber's tensegrity theory also led to the prediction in the early 1980s that changes in extracellular matrix structure and mechanics play a fundamental role in tissue and organ development, and that deregulation of this form of developmental control can promote cancer formation.
Ingber's contributions in translational medicine include discovery of one of the first angiogenesis inhibitor compounds (TNP-470) to enter clinical trials for cancer, creation of tissue engineering scaffolds that led to clinical products, development of a dialysis-like blood cleansing device for treatment of blood stream infections that is moving towards clinical testing, creation of a mechanically-activated nanotechnology for targeting clot-busting drugs to sites of vascular occlusion, and co-development of a new surface coating based on Slippery Liquid Infused Porous Surfaces (SLIPS) for medical devices and implants that could eliminate the conventional dependency on anticoagulant drugs that pose life-threatening side-effect risks.
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Donald E. Ingber
Donald E. Ingber (born 1956)[citation needed] is an American cell biologist and bioengineer. He is the founding director of the Wyss Institute for Biologically Inspired Engineering at Harvard University, the Judah Folkman Professor of Vascular Biology at Harvard Medical School and Boston Children's Hospital, and Professor of Bioengineering at the Harvard John A. Paulson School of Engineering and Applied Sciences. He is also a member of the American Institute for Medical and Biological Engineering, the National Academy of Engineering, the National Academy of Medicine, the National Academy of Inventors, and the American Academy of Arts and Sciences.
Ingber is a founder of the emerging fields of biologically inspired engineering. He has made pioneering contributions to numerous other disciplines including mechanobiology, cytoskeletal biology, extracellular matrix biology, integrin signaling, tumor angiogenesis, tissue engineering, nanobiotechnology, systems biology, and translational medicine. Ingber has authored more than 470 publications in scientific journals and books, and is an inventor on more than 190 patents spanning anti-cancer therapeutics, tissue engineering, medical devices, drug delivery systems, biomimetic materials, nanotherapeutics, and bioinformatics software.
Ingber has been scientific founder of five companies: Neomorphics, Inc., a tissue engineering startup which led to clinical products through subsequent acquisitions (Advanced Tissue Sciences Inc.); Tensegra, Inc. (formerly known as Molecular Geodesics, Inc.,) which 3D-printed medical devices; and most recently, Emulate, Inc., which formed to commercialize human "organs-on-chips" that accelerate drug development, detect toxicities and advance personalized medicine by replacing animal testing; Boa Biomedical, Inc. (originally known as Opsonix, Inc.), which aims to reduce deaths due to sepsis and blood infections by removing pathogens from the blood; and FreeFlow Medical Devices, LLC, which develops special coatings for medical devices to eliminate the formation of blood clots and biofilms on materials.
Ingber grew up in East Meadow, New York. He received a combined B.A./M.A. in molecular biophysics and biochemistry from Yale College and Yale Graduate School of Arts and Sciences in 1977; an M.Phil. in cell biology from Yale Graduate School of Arts and Sciences in 1981; and a combined M.D./Ph.D. from Yale School of Medicine and Yale Graduate School of Arts and Sciences in 1984.[citation needed] At Yale, he carried out undergraduate research on DNA repair with Paul Howard-Flanders, and on cancer metastasis with Alan Sartorelli.
Ingber worked on development of cancer therapeutics[citation needed] with Kenneth Harrap at the Royal Cancer Hospital/Royal Marsden Hospital in England, with support from a Bates Traveling Fellowship. He carried out his Ph.D. dissertation research under the direction of Dr. James Jamieson in the department of cell biology, and his advisory committee included George Palade, Elizabeth Hay and Joseph Madri. From 1984 to 1986 he completed his training as an Anna Fuller Postdoctoral Fellow under the mentorship of Dr. Judah Folkman in the Surgical Research Laboratory at Boston Children's Hospital and Harvard Medical School.
Ingber is best known for his discovery of the role mechanical forces play in developmental control and in cancer formation, and for his application of these principles to develop bioinspired medical devices, nanotechnologies, and therapeutics. Ingber's early scientific work led to the discovery that tensegrity architecture - first described by the architect Buckminster Fuller and the sculptor Kenneth Snelson - is a fundamental design principle that governs how living systems are structured, from individual molecules and cells to whole tissues, organs and organisms.
Ingber's work on tensegrity led him to propose that mechanical forces play as important a role in biological control as chemicals and genes do, and to investigate the molecular mechanism by which cells convert mechanical signals into changes in intracellular biochemistry and gene expression, a process known as "mechanotransduction." Ingber determined that living cells use tensegrity architecture to stabilize their shape and cytoskeleton, that cellular integrins function as mechanosensors on the cell surface, and that cytoskeletal tension (or "prestress," which is central to the stability of tensegrity structures) is a fundamental regulator of many cellular responses to mechanical cues. Ingber's tensegrity theory also led to the prediction in the early 1980s that changes in extracellular matrix structure and mechanics play a fundamental role in tissue and organ development, and that deregulation of this form of developmental control can promote cancer formation.
Ingber's contributions in translational medicine include discovery of one of the first angiogenesis inhibitor compounds (TNP-470) to enter clinical trials for cancer, creation of tissue engineering scaffolds that led to clinical products, development of a dialysis-like blood cleansing device for treatment of blood stream infections that is moving towards clinical testing, creation of a mechanically-activated nanotechnology for targeting clot-busting drugs to sites of vascular occlusion, and co-development of a new surface coating based on Slippery Liquid Infused Porous Surfaces (SLIPS) for medical devices and implants that could eliminate the conventional dependency on anticoagulant drugs that pose life-threatening side-effect risks.
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