Dororo (どろろ) is a Japanese manga series written and illustrated by the manga artist Osamu Tezuka. Tezuka's childhood memory of his friends pronouncing dorobō (どろぼう; "thief") as dororo inspired the title of the series. Dororo was first serialized in Shogakukan's Weekly Shōnen Sunday between August 1967 and July 1968, before being cancelled. The manga was then concluded in Akita Shoten's Bōken'ō magazine in 1969. The story revolves around the rōnin samurai Hyakkimaru and child thief Dororo on their journey through Sengoku era Japan.

A 26-episode anime television series adaptation produced by Mushi Productions aired in 1969. The anime series bears the distinction of being the first entry in what is now known as the World Masterpiece Theater series (Calpis Comic Theater at the time). Dororo was also made into a live-action film in 2007. A 24-episode second anime television series adaptation by MAPPA and Tezuka Productions aired from January to June 2019.

During the Sengoku period, a rōnin named Hyakkimaru (百鬼丸) wanders the land alongside a young orphaned thief named Dororo (どろろ). Hyakkimaru is born severely disfigured, lacking limbs, facial features, and internal organs as a result of a pact made by his father, the daimyō Kagemitsu Daigō, with 48 demons. In exchange for power and prosperity over his domain, Kagemitsu offers the demons anything they desire from him, allowing them to wreak havoc upon the land. To save him from execution, Hyakkimaru's mother, Nui no Kata, sets him adrift on a river, where Jukai, a skilled medicine man, discovers and raises him. Jukai crafts prostheses for the child using the remains of deceased war orphans, rendering him nearly invulnerable to mortal injuries. Embedded within his left arm is a mystical blade, gifted by a traveling storyteller who believes it destined for Hyakkimaru due to the doctor's frequent encounters with goblins since finding the boy. The blade, forged for vengeance against supernatural beings, becomes a vital weapon in Hyakkimaru's quest. Forced to leave Jukai after attracting demons, Hyakkimaru learns from a spectral voice that slaying the demons will restore his stolen body parts. Over time, he earns the name Hyakkimaru for his fearsome, inhuman nature.

During his travels, Hyakkimaru encounters Dororo, a young thief who joins him in traversing the war-torn countryside. By then, Hyakkimaru has already slain 15 demons. As their journey continues, he vanquishes six more, gradually reclaiming fragments of his humanity. Along the way, Dororo's past is revealed: the child's father, the bandit Hibukuro, steals wealth from oppressive samurai and hides it at Bone Cape, intending to distribute it among the suffering populace. Betrayed by his subordinate Itachi, Hibukuro is crippled but manages to escape with his wife, Ojiya, and their child. Though Hibukuro perishes aiding their flight, Ojiya, fearing her own death, prays to Buddha and inscribes a map in her own blood to guide Dororo to the treasure before succumbing to the cold.

Itachi later captures Dororo, using the map on the child's back to locate Bone Cape. A mysterious boatman ferries them, accompanied by two demonic sharks that attack the bandits. Though one shark devours half of Itachi's men, Dororo and the survivors kill the creature. When the boatman returns with the second shark, Hyakkimaru intervenes, wounding the beast before it flees. After landing, the boatman lures the remaining bandits to a poisoned spring, leaving only Itachi, Dororo, and Hyakkimaru. Discovering the corpses, Hyakkimaru slays the shark and the boatman, regaining his voice in the process. Itachi searches for the treasure but finds only a letter from Hibukuro stating it has been moved. When corrupt magistrates arrive under false pretenses, Hyakkimaru, Dororo, and Itachi fight them off, though Itachi is left mortally wounded.

Later, Hyakkimaru learns that his father has been possessed by the remaining demons and seeks to confront him. The Daigō domain has fallen into ruin, with enslaved citizens forced to construct a fortress. Though the slaves plot rebellion, a traitor alerts Kagemitsu, who massacres them with archers. The survivors retreat into a hidden tunnel. Hyakkimaru infiltrates the fortress while Dororo joins the slaves' ambush, only to be captured. To test his son's loyalty, Kagemitsu orders Hyakkimaru to execute Dororo. Pretending to comply, Hyakkimaru instead hurls his sword into the darkness, striking the physical manifestation of the demons. Though some escape, the slaves surge forth, overwhelming Kagemitsu's forces. Weakened by the demons' deaths, Kagemitsu flees with Nui.

After regaining his eyes, Hyakkimaru realizes Dororo is female, though the child adamantly identifies as male, having been raised as a boy to endure hardship. Encouraging Dororo to embrace strength as a farmer's child, Hyakkimaru gifts the coveted sword before departing alone to continue his quest, promising to reunite once his body is whole. Decades later, the last of the 48 demons is finally slain.

Characters and voice actors appearing in the anime and video game.