Drena (Dréna in local dialect) is a comune (municipality) in Trentino in the northern Italian region Trentino-Alto Adige/Südtirol, located about 15 kilometres (9 mi) southwest of Trento. As of 31 December 2004, it had a population of 476 and an area of 8.4 square kilometres (3.2 sq mi).

Drena borders the following municipalities: Dro, Cavedine, Arco and Villa Lagarina.