ETS domain-containing protein Elk-3 is a protein that in humans is encoded by the ELK3 gene.

The protein encoded by this gene is a member of the ETS-domain transcription factor family and the ternary complex factor (TCF) subfamily. Proteins in this subfamily regulate transcription when recruited by serum response factor to bind to serum response elements. This protein is activated by signal-induced phosphorylation; studies in rodents suggest that it is a transcriptional inhibitor in the absence of Ras, but activates transcription when Ras is present.

ELK3 has been shown to interact with TCF3.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.