East Saint Louis Senior High School is the only high school in East St. Louis, Illinois. The school serves about 1,438 students in grades 9 to 12 in the East Saint Louis Public Schools district. It was featured in the Jonathan Kozol book Savage Inequalities. In 1998, East St. Louis Lincoln High School consolidated with East St. Louis High.

In addition to East St. Louis, the district (this is the sole comprehensive high school of the district) also includes portions of Canteen, Centreville, and Stites Townships in northwestern St. Clair County. The district also includes all of Washington Park, much of Alorton and Centreville, and portions of Belleville, Caseyville, Fairmont City, Fairview Heights, and Madison.

East St. Louis Senior High School won the 2008 Class 7A football state championship against Geneva High School. The Flyers have a storied history in Illinois high school football, having won the state championship over a half-dozen times and the national championship twice. The Flyers beat Prairie Ridge in 2022 for the Class 6A football title. From 1976 to the beginning of the 1995 season, the Flyers' coach was Bob Shannon. Two years of Flyers football during that period were the subject of a book, The Right Kind of Heroes.

The Flyers compete in the Southwestern Conference.