Edmond Santa Fe High School is a public high school located in Edmond, Oklahoma, United States. Founded in 1993, Santa Fe is one of three traditional high schools in the Edmond Public Schools district, along with Edmond Memorial High School and Edmond North High School. The school's mascot is the Wolf and the school colors are forest green and gray.

The high school opened in 1993 along with Edmond North High School. In its first year, Santa Fe had only freshman and sophomore students; those initial sophomores were the school's first graduating class in 1996. It was recognized as a Blue Ribbon School of Excellence by No Child Left Behind in the 2011–2012 school year.

Santa Fe's athletic teams are nicknamed the Wolves.

The school fields two competitive show choirs, "Finale" (Mixed) and "Serenade" (Treble) which have won competitions in Oklahoma. The school also hosts an annual competition.

Santa Fe also has a competitive marching band. This marching band received eighth place at Bands of America St Louis regional in 2025

35°38′27″N 97°30′33″W / 35.640742°N 97.509034°W / 35.640742; -97.509034