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Elaine Bearer
Elaine L. Bearer is an American neuroscientist, pathologist, and composer.
Bearer received her Bachelor's of Music from The Manhattan School of Music in Theory, in June 1970. She received the Masters of Art from New York University, where her thesis was Structural Innovation in the String Quartets of Haydn. Prior to studies at The Manhattan School, Bearer was a pupil of Nadia Boulanger, first at the Ecole Americaine des Beaux Arts in Fontainebleau and continuing in Boulanger's home on Rue Ballu in Paris. She received the combined MD-PhD degree from University of California San Francisco (UCSF).
After a one-year post-doctoral fellowship with Lelio Orci in Geneva, Bearer returned to UCSF for residency and fellowship training—clinically in Pathology and Medical Genetics with Charlie Epstein, and scientifically in Biochemistry and Biophysics with Bruce Alberts. She was recruited to a tenure track position at Brown University in 1991 and rose in the ranks to full professorship. In 2009 University of New Mexico recruited her to an endowed tenured professorship and as Vice Chair for Research.
Bearer studied neurophysiology in John G. Nicholl's lab at Stanford University. Bearer's early scientific contributions as a graduate student include the first ultrastructural imaging of lipid rafts in cell membranes that mediate neuronal signaling (Bearer and Friend, J. Cell Biol., 1982); then as a post-doc the first ultrastructural imaging of endothelial fenestral diaphragms that allow transport of solutes between blood and tissue (Bearer and Orci, J. Cell Biol., 1985), and the first biochemical discovery of Arp2 and 2E4/kaptin, proteins that regulate actin dynamics in neurons (Bearer, 1992) and platelets. While a Principal Investigator in her own lab at Brown University, Bearer discovered that these proteins, initially identified while Bearer was a post-doc at UCSF, turned out to be major regulatory components of the length of stereocilia in the hearing apparatus of the inner ear.
Bearer turned to brain-wide imaging by magnetic resonance imaging in living animals over time during a sabbatical from Brown to Caltech in 2004–2005. This new venture resulted in multiple contributions since 2007 include imaging of the brain in living mouse models of human neuropsychological disorders, such as Down syndrome, Alzheimer's disease, fear to anxiety transitions, viral infections of the brain, and drugs of abuse. Together with collaborator Russell E. Jacobs, Bearer developed and deployed longitudinal manganese-enhanced magnetic resonance imaging (MEMRI) coupled with behavior, transgenic mouse models, biochemistry, and optical microscopy to explore brain-wide responses to experience and disease over time.
Since 2009, Bearer has been the Harvey Family Professor in Pathology at University of New Mexico, a visitor at California Institute of Technology, and an Elected Fellow of the American Association for the Advancement of Science. Bearer is also a fellow of the College of American Pathologists.
In 2019 The Manhattan School awarded Bearer the Distinguished Alumni Award, and in 2020, she received a Campaign Alumni Award for "most audacious" from University of California, San Francisco. In 2021 she has been bestowed with an honorary professorship from The Strömstad Akademi, in Sweden, a Nordic Academy for Advanced Studies. Her newly composed string quartet premiered at the award ceremony.
Bearer's research began with studies of membrane dynamics involved in synaptic transmitter release. She developed imaging labels for anionic lipids and made the earliest observations of membrane lipid rafts. and the protein biochemistry of actin modulators During this investigation, she identified proteins that drive filament formation and mapped one, kaptin/2E4, on human chromosome 19. This work revealed that mutations in the promoter region of kaptin/2E4 lead to inherited deafness.
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Elaine Bearer
Elaine L. Bearer is an American neuroscientist, pathologist, and composer.
Bearer received her Bachelor's of Music from The Manhattan School of Music in Theory, in June 1970. She received the Masters of Art from New York University, where her thesis was Structural Innovation in the String Quartets of Haydn. Prior to studies at The Manhattan School, Bearer was a pupil of Nadia Boulanger, first at the Ecole Americaine des Beaux Arts in Fontainebleau and continuing in Boulanger's home on Rue Ballu in Paris. She received the combined MD-PhD degree from University of California San Francisco (UCSF).
After a one-year post-doctoral fellowship with Lelio Orci in Geneva, Bearer returned to UCSF for residency and fellowship training—clinically in Pathology and Medical Genetics with Charlie Epstein, and scientifically in Biochemistry and Biophysics with Bruce Alberts. She was recruited to a tenure track position at Brown University in 1991 and rose in the ranks to full professorship. In 2009 University of New Mexico recruited her to an endowed tenured professorship and as Vice Chair for Research.
Bearer studied neurophysiology in John G. Nicholl's lab at Stanford University. Bearer's early scientific contributions as a graduate student include the first ultrastructural imaging of lipid rafts in cell membranes that mediate neuronal signaling (Bearer and Friend, J. Cell Biol., 1982); then as a post-doc the first ultrastructural imaging of endothelial fenestral diaphragms that allow transport of solutes between blood and tissue (Bearer and Orci, J. Cell Biol., 1985), and the first biochemical discovery of Arp2 and 2E4/kaptin, proteins that regulate actin dynamics in neurons (Bearer, 1992) and platelets. While a Principal Investigator in her own lab at Brown University, Bearer discovered that these proteins, initially identified while Bearer was a post-doc at UCSF, turned out to be major regulatory components of the length of stereocilia in the hearing apparatus of the inner ear.
Bearer turned to brain-wide imaging by magnetic resonance imaging in living animals over time during a sabbatical from Brown to Caltech in 2004–2005. This new venture resulted in multiple contributions since 2007 include imaging of the brain in living mouse models of human neuropsychological disorders, such as Down syndrome, Alzheimer's disease, fear to anxiety transitions, viral infections of the brain, and drugs of abuse. Together with collaborator Russell E. Jacobs, Bearer developed and deployed longitudinal manganese-enhanced magnetic resonance imaging (MEMRI) coupled with behavior, transgenic mouse models, biochemistry, and optical microscopy to explore brain-wide responses to experience and disease over time.
Since 2009, Bearer has been the Harvey Family Professor in Pathology at University of New Mexico, a visitor at California Institute of Technology, and an Elected Fellow of the American Association for the Advancement of Science. Bearer is also a fellow of the College of American Pathologists.
In 2019 The Manhattan School awarded Bearer the Distinguished Alumni Award, and in 2020, she received a Campaign Alumni Award for "most audacious" from University of California, San Francisco. In 2021 she has been bestowed with an honorary professorship from The Strömstad Akademi, in Sweden, a Nordic Academy for Advanced Studies. Her newly composed string quartet premiered at the award ceremony.
Bearer's research began with studies of membrane dynamics involved in synaptic transmitter release. She developed imaging labels for anionic lipids and made the earliest observations of membrane lipid rafts. and the protein biochemistry of actin modulators During this investigation, she identified proteins that drive filament formation and mapped one, kaptin/2E4, on human chromosome 19. This work revealed that mutations in the promoter region of kaptin/2E4 lead to inherited deafness.