Elisa's upbringing in Galați exposed her to a family that, despite societal constraints, encouraged her intellectual pursuits. Her father, Atanase Leonida, was a military officer and his career surely influenced her resolve and dicipline. Her mother, Matilda Gill, being of French origin might also have influenced her openness to pursue study in Berlin.

Elisa Leonida married Constantin Zamfirescu, a chemist and the brother of writer Duiliu Zamfirescu. The marriage provided her with a supportive partnership.

Elisa and Constantin welcomed their daughter, Cornelia Zamfirescu, into the world. Elisa juggled her family responsibilities with her demanding career, demonstrating her ability to balance multiple roles.

Details about Elisa's everyday family life are somewhat limited, but historical accounts suggest she was a dedicated mother and wife, actively involved in her daughter's upbringing and education. Her family life was interwoven with her commitment to her profession, making her a role model for women.

Even in her later years, Elisa remained close to her family, providing support and guidance to her daughter and grandchildren. Her family was a source of strength and inspiration throughout her life.