Erinsborough is a fictional suburb of Melbourne, Australia, where the soap opera Neighbours is set, focusing on the domestic and professional lives of the people who live and work there. Neighbours primarily centers on the residents of Ramsay Street and other Erinsborough locations, most prominently those situated within the Lassiters complex. Erinsborough is a loose anagram of Neighbours.

Erinsborough High School, a fictional high school, has been featured onscreen since Neighbours began in 1985. It is a co-educational high school, and in its fictional history, it was opened shortly after the Second World War. Many of the characters have been seen attending or working there over the years. The Blackburn English Language Centre in Burwood East, Victoria, and Coburg High School have both been used for location and exterior shots. Kenneth Muir (Roger Boyce) was principal of the school when the series began and Erinsborough High was regularly seen until 1986, when Scott Robinson (Jason Donovan), Charlene Mitchell (Kylie Minogue), Mike Young (Guy Pearce) and Jane Harris (Annie Jones) graduated. The school was not seen again onscreen until late 1988.

The set features a corridor, a stairwell, an office, and a classroom. Other areas of the school, including the playground and changing rooms, have been featured over the years. In 2010, the layout of the classroom was changed as was the school logo. Neighbours' oldest surviving prop is the school's emblem and motto, which is stuck on the doors leading from the car park to the studios. "Erinsborough High School: Sapienter Si Sincere" means wisdom and success. Onscreen, Erinsborough High has faced the threat of closure four times, in 1991, 1997, 2015 and 2023 and the school has been merged with both West Waratah Tech and West Waratah High.

Erinsborough High's uniform has also been through numerous changes, with the maroon jumper being the most consistent item. A storyline that aired in October 2015 saw a fire destroy part of the school and trap several characters inside.

A spin-off series based in the school setting titled Neighbours: Erinsborough High was released digitally in November 2019. The spin-off was summarised as focusing on "bullying, mental illness, sexuality, cultural diversity, parental and peer pressure, and teacher-student relationships."

In May 2011, Erinsborough High came fourth out of four in a poll run by Inside Soap to find reader's favourite fictional school, which they would most like to attend. Erinsborough High received 16% of the vote.

In the 2023 revamped series, Jane Harris is the principal of Erinsborough High. Former principal Susan Kennedy has retired, while Ramsay street residents Nell Rebecchi, JJ and Dex Varga-Murphy, are students at the school. Wendy Rodwell (Candice Leask) is later hired as a teacher at the school.

Offscreen the interior school sets are shared with the sets of Erinsborough Hospital.^{[citation needed]}