European route E 58 is a road part of the International E-road network. It begins in Vienna, Austria, and passing through Slovakia, Ukraine, Romania and Moldova, ends in Rostov-on-Don, Russia. It is approximately 2,200 km (1,400 mi) long.

Since 2014, a part of the road in eastern Ukraine has been under the control of the separatist Donetsk People's Republic. During the 2022 Russian invasion of Ukraine, Russia took direct control of areas of the road in Donbas, Kherson Oblast and Zaporizhzhia Oblast.