In artificial intelligence (AI), an expert system is a computer system emulating the decision-making ability of a human expert. Expert systems are designed to solve complex problems by reasoning through bodies of knowledge, represented mainly as if–then rules rather than through conventional procedural programming code. Expert systems were among the first truly successful forms of AI software. They were created in the 1970s and then proliferated in the 1980s, being then widely regarded as the future of AI — before the advent of successful artificial neural networks. An expert system is divided into two subsystems: 1) a knowledge base, which represents facts and rules; and 2) an inference engine, which applies the rules to the known facts to deduce new facts, and can include explaining and debugging abilities.

Soon after the dawn of modern computers in the late 1940s and early 1950s, researchers started realizing the immense potential these machines had for modern society. One of the first challenges was to make such machines able to “think” like humans – in particular, making these machines able to make important decisions the way humans do. The medical–healthcare field presented the tantalizing challenge of enabling these machines to make medical diagnostic decisions.

Thus, in the late 1950s, right after the information age had fully arrived, researchers started experimenting with the prospect of using computer technology to emulate human decision making. For example, biomedical researchers started creating computer-aided systems for diagnostic applications in medicine and biology. These early diagnostic systems used patients’ symptoms and laboratory test results as inputs to generate a diagnostic outcome. These systems were often described as the early forms of expert systems. However, researchers realized that there were significant limits when using traditional methods such as flow charts, statistical pattern matching, or probability theory.

This previous situation gradually led to the development of expert systems, which used knowledge-based approaches. These expert systems in medicine were the MYCIN expert system, the Internist-I expert system and later, in the middle of the 1980s, the CADUCEUS.

Expert systems were formally introduced around 1965 by the Stanford Heuristic Programming Project led by Edward Feigenbaum, who is sometimes termed the "father of expert systems"; other key early contributors were Bruce Buchanan and Randall Davis. The Stanford researchers tried to identify domains where expertise was highly valued and complex, such as diagnosing infectious diseases (Mycin) and identifying unknown organic molecules (Dendral). The idea that "intelligent systems derive their power from the knowledge they possess rather than from the specific formalisms and inference schemes they use" – as Feigenbaum said – was at the time a significant step forward, since the past research had been focused on heuristic computational methods, culminating in attempts to develop very general-purpose problem solvers (foremostly the conjunct work of Allen Newell and Herbert Simon). Expert systems became some of the first truly successful forms of artificial intelligence (AI) software.

Research on expert systems was also active in Europe. In the US, the focus tended to be on the use of production rule systems, first on systems hard coded on top of Lisp programming environments and then on expert system shells developed by vendors such as Intellicorp. In Europe, research focused more on systems and expert systems shells developed in Prolog. The advantage of Prolog systems was that they employed a form of rule-based programming that was based on formal logic.

One such early expert system shell based on Prolog was APES. One of the first use cases of Prolog and APES was in the legal area namely, the encoding of a large portion of the British Nationality Act. Lance Elliot wrote: "The British Nationality Act was passed in 1981 and shortly thereafter was used as a means of showcasing the efficacy of using Artificial Intelligence (AI) techniques and technologies, doing so to explore how the at-the-time newly enacted statutory law might be encoded into a computerized logic-based formalization. A now oft-cited research paper entitled “The British Nationality Act as a Logic Program” was published in 1986 and subsequently became a hallmark for subsequent work in AI and the law."

In the 1980s, expert systems proliferated. Universities offered expert system courses and two-thirds of the Fortune 500 companies applied the technology in daily business activities. Interest was international with the Fifth Generation Computer Systems project in Japan and increased research funding in Europe.