Falling Creek Ironworks was the first iron production facility in North America. It was established by the Virginia Company of London in Henrico Cittie (sic) on Falling Creek near its confluence with the James River. It was short-lived due to an attack by Native Americans in 1622.

The long-lost site was rediscovered in the early 21st century. It is now located in Chesterfield County, about 5 miles (8.0 km) south of the fall line of the James River at present-day Richmond, Virginia. Archaeological and related research work at the site was ongoing as of March 2007.

The geology of Virginia's terrain changes from the sandy coastal plain of the Tidewater Region to the more hilly and rocky Piedmont Region along the north-south Fall Line. At Richmond, the generally west to east flowing James River turns almost due south and essentially flows parallel to and just east of the fall line for about 8 miles (13 km), before turning east again near Drewry's Bluff. On the west bank of this section, the Piedmont terrain contained the ore deposits needed to make iron, but was still adjacent to the navigable portion of the James River through the Tidewater Region. A local tributary, Falling Creek, flowed downhill into the James River, providing the water power needed.

The proprietary Virginia Company of London established the first permanent English settlement in the Virginia Colony at Jamestown on May 14, 1607. The young colony struggled for years to develop self-sufficiency and successful exports. During the first five years, most of the colonists died from disease, starvation, and attacks by the Native Americans.

After 1612, non-native strains of tobacco were used as a cash crop, and plantations and other outposts from Jamestown spread downstream and up the James River toward the head of navigation (fall line) at present-day Richmond.

Near the confluence of Falling Creek with the James River, the colonists identified the site with the combination of ore deposits, water power, and access to navigable waters for shipping which were needed for their desired iron production facility. Although the outpost was one of the most remote from Jamestown, beginning in 1619, the Falling Creek Ironworks was established there. It was the first iron production facility in North America.

Records which have survived indicate that the ironworks was able to produce some quantity of iron. However, from the extant records, it cannot be determined whether the ironworks had begun full production before operations were interrupted by the Indian massacre of 1622.

On March 22, 1622, the Powhatan Confederacy of Native Americans tribes under the leadership of Chief Opechancanough conducted a series of coordinated surprise attacks on almost all the English settlements along the James River. Jamestown was spared only due to a timely warning. The massacre resulted in the death of about a third of the colonists. Two women and three children were among the 27 killed at Falling Creek Ironworks, leaving only two colonists alive, and the facilities were destroyed. Sir Thomas Dale's progressive development a few miles downstream at Henricus was evacuated as a result.