Feline vaccination is animal vaccination applied to cats. Vaccination plays a vital role in protecting cats from infectious diseases, some of which are potentially fatal. They can be exposed to these diseases from their environment, other pets, or even humans.

The practice of recommending and giving vaccines on a fixed schedule with annual boosters has been widely discarded. Current recommendations are based on the philosophy of vaccinating each cat no more frequently than necessary. These recommendations take into account considerations for the efficacy and duration of immunity (DOI) of available vaccines; environmental risks and likelihood of exposure; the specific needs and risks associated with age and overall health status of different cats and cat populations; and socioeconomic limitations.

Recommendation vary for:

Specific consideration may be required for:

Core vaccines are ones that are considered "essential for health" and are recommended for both indoor and outdoor owned domestic cats, as well as community and feral cats. These include:

Non-core vaccines are recommended only for cats at risk of specific infection. These include:

National, international, and global vaccination guidelines by professional veterinary advisory boards are regularly updated and available for on-line viewing or download. These include:

These guides provide recommendations for kittens and adult cats. They include initial requirements to establish adequate levels of acquired immunity, along with renewal (booster) recommendations to retain it. For some infectious diseases, blood samples can be used to measure antibody levels (titers) to determine DOI. Though these tests do not provide evidence of protective immunity, some clinicians use high titer results as an indicator, along with low disease exposure risk that vaccines might be administered at a longer than usual revaccination interval.