First Lady of Uruguay (Spanish: Primera Dama de Uruguay) is the unofficial and protocol title of the wife of the president of Uruguay, and hostess of Suarez Residence. The first lady is not an elected position, carries no official duties and brings no salary, but is traditionally responsible for directing and coordinating activities in the social field of the presidency and also accompany the president in ceremonies or official activities.

The role is currently held by Laura Alonso Pérez, who is the spouse of president Yamandú Orsi.