Flamingo is the southernmost headquarters of Everglades National Park, in Monroe County, Florida, United States. Flamingo is one of the two end points of the 99-mile (159-km) Wilderness Waterway (with another end point at Gulf Coast Visitor Center in the Everglades City), and the southern end of the only road (running 39.3 miles (63.2 km)) through the park from Florida City. It began as a small coastal settlement on the eastern end of Cape Sable on the southern tip of the Florida peninsula, facing Florida Bay. The actual town of Flamingo was located approximately 4+1⁄2 miles west of the current Flamingo campground area. All that remains of the former town are a few remnants of building foundations, and it is considered a ghost town.

Flamingo was first settled circa 1892, although Tequesta Indians had lived in the area prior to that. The settlers made a living by providing fish, fresh vegetables and charcoal to Key West.

The settlement received its name in 1893 when the settlers had to choose a name for their new post office. They chose the flamingo as it was the most distinctive bird seen in the area. While the flamingo did not breed in Florida, birds from Cuba and the Bahamas once traveled in large numbers to the area. Flamingos were last seen in large numbers in the area in 1902. The post office closed in 1909.

Leverett White Brownell, a naturalist, visited Flamingo in 1893. He described the village of 38 "shacks" on stilts as infested with fleas and mosquitoes. He claimed to have seen an oil lamp extinguished by a cloud of mosquitoes. He also stated that flea powder was the "staff of life" and that the cabins were thickly sooted from the use of smudge pots. He added that tomatoes, asparagus and eggplant were the principal crops.

Flamingo had a small boom in the early 20th century when speculators thought that Henry Flagler would choose a route for his Florida East Coast Railway across Florida Bay to Key West. By 1900, about 50 families lived in Flamingo, and it had a Monroe County school. Nearby rookeries, such as the famed Cuthbert Rookery, became popular with poachers who sought to kill the nesting birds for their plumage, which was used for fashionable women's hats. Resident and early game warden Guy Bradley was shot and killed in Flamingo after confronting plume hunters. Public rage over the murder directly led to federal legislation outlawing the practice.

A fish house was built in Flamingo in 1908 and fishing became the primary occupation of the town, but by 1910, only three homes remained occupied in Flamingo. The Ingraham Highway from Homestead reached Flamingo in 1922 but was poorly maintained and virtually impassable in wet weather until the National Park Service gave it a gravel top in the late 1940s. During Prohibition, moonshining became a major occupation in Flamingo but was eventually suppressed by government agents.

The Snake Bight Trail provides an alternate pedestrian access to the sea to the east of Flamingo but its two-mile length is notorious for the number and ferocity of the mosquitoes. The Christian Point Trail is less daunting and leads through open saltwater marl prairie to Christian Point. The area reportedly got its name when the Labor Day Hurricane of 1935 washed numerous dead bodies from the Keys ashore.

Flamingo experiences a tropical savanna climate (Köppen climate classification Aw) in which all twelve months have mean temperatures of at least 18 °C (64 °F). Summers are hot and humid and high temperatures average between 89° and 91 °F (31° to 33 °C). Winters are warm and dry.