Florida State Road 739

State Road 739 (SR 739) is a 17-mile-long (27 km) commercial highway running from San Carlos Park, Florida to North Fort Myers that is also known as U.S. Route 41 Business for the northernmost six miles (9.7 km) of its route.

The southern terminus of SR 739 is an intersection with US 41 near San Carlos Park. SR 739 is known as Michael G. Rippe Parkway for its first three miles. Immediately north of the southern terminus is an interchange with Alico Road (CR 840) which includes only a southbound exit and northbound entrance. SR 739 crosses the interchange and the Seminole Gulf Railway on a large overpass. From the Alico interchange, SR 739 becomes six lanes and continues north, paralleling the Seminole Gulf Railway and passing through the Briarcliff neighborhood.

At its intersection with Six Mile Cypress Parkway (SR 865) in south Fort Myers, SR 739 becomes known as Metro Parkway and continues northward. It is reduced to five lanes with a middle turn lane at the intersection with Daniels Parkway (CR 876). SR 739 then passes to the east of the Villas neighborhood, Page Field, and the Chico's World Headquarters. It intersects with Colonial Boulevard (SR 884), Lee County's primary east–west highway, shortly after entering Fort Myers city limits.

At Winkler Avenue, SR 739 becomes six lanes again and turns northwest. An overpass carries it over the Ten Mile Canal and the Seminole Gulf Railway's freight yard. At LeeTran Boulevard, the northbound lanes continue onto Evans Avenue, while the southbound lanes connect to Fowler Street.

SR 739 continues north along Evans Avenue and Fowler Street. Currently, Evans Avenue is a one-way street north of LeeTran Boulevard, and has three northbound lanes while Fowler Street carries four lanes of bi-directional traffic. This unusual configuration continues to just south of downtown Fort Myers at the intersection of State Road 82 (Dr. Martin Luther King Jr. Boulevard). Fowler Street's northbound lanes terminate at SR 82, and from here north, Evans Avenue (which becomes Park Avenue shortly after SR 82) carries all northbound traffic, and Fowler Street carries all southbound traffic with three lanes each.

At the intersection with SR 80 just east of downtown Fort Myers, SR 739 becomes concurrent with U.S. Route 41 Business, and SR 739 becomes a hidden designation from this point north. It then intersects SR 80 and crosses the Caloosahatchee River on the Edison Bridge. The northbound and southbound streets rejoin into a single six-lane roadway at the north end of the Edison Bridge spans, and travel into North Fort Myers, Florida along the original Tamiami Trail.

SR 739 is then reduced to four lanes divided after the intersection of Pine Island Road/Bayshore Road (SR 78), and terminates shortly after at the mainline of US 41 north of North Fort Myers.

Fowler Street and Evans Avenue (which carry SR 739 near Downtown Fort Myers) were early city streets. Evans Avenue is named for Major James Evans, the founder of Fort Myers. Fowler Street is named for Captain W.H. Fowler, a U.S. soldier who fought in the Seminole Wars. Fowler's grave was discovered in 1885 in a military cemetery that once existed near the intersection of Fowler and Second streets. Francis A. Hendry, one of the first councilmen of Fort Myers, proposed naming the street after Fowler. Today, a historic plaque on Fowler Street near Second Street marks the location of the former cemetery.