Fort Center is an archaeological site in Glades County, Florida, United States, a few miles northwest of Lake Okeechobee. It was occupied for more than 2,000 years, from 450 BCE until about 1700 CE. The inhabitants of Fort Center may have been cultivating maize centuries before it appeared anywhere else in Florida.

The area around Fisheating Creek was occupied by people of the Belle Glade culture from as early as 1000 BCE.

Fort Center is a complex of earthwork mounds, linear embankments, middens, circular ditches, and an artificial pond occupying an area approximately 1 mile (1.6 km) long and 0.5 miles (0.80 km) wide extending east-west along Fisheating Creek, a stream that empties unto Lake Okeechobee.

The site is named for a US Army fortification, "Fort Center", used during the Seminole Wars.

The Fort Center site consists of three environments: a meander belt along the stream consisting of a floodplain swamp and natural levees, wet prairie, and oak-cabbage palm-saw palmetto hammocks. The floodplain and prairie are subject to frequent flooding. The prairie consists of two to four feet of sandy soil on a hardpan, resulting in poor drainage. The stream meander belt cuts below the hardpan.

Pollen evidence shows that the river meander belt and prairie existed in essentially their current condition since human occupation began 2,500 to 3,000 years ago until the 20th century. The area covered by hammocks has increased since sustained occupation ended around 1700. Much of the area around Fort Center was developed as improved pasture during the 20th century. Lake Okeechobee was surrounded by a system of dikes built during the 20th century, except for where Fisheating Creek enters the lake.

Fort Center is in the Lake Okeechobee Basin, an area that surrounds and drains into Lake Okeechobee, and is synonymous with the Belle Glade culture area, one of several related culture areas in southern Florida. The people of the Belle Glade culture occupied the area around Fisheating Creek from as early as 1000 BCE until historic times. The Kissimmee River valley is usually regarded as a sub-area of the Lake Okeechobee Basin (Belle Glade culture area). Sears treats the Lake Okeechobee Basin, including the Kissimmee River Valley, as a sub-region of the Glades culture area, while others place the Belle Glade (Lake Okeechobee) and Glades areas on an equal footing. The cultural traditions of southern Florida had a long history and were well adapted to the area. Archaeological evidence of changes in those cultures is mostly limited to small changes in the few ceramics that were decorated.

Mounds, ditches, canals and other earthworks have been found at a number of locations in interior southern Florida. More than thirty sites of the Belle Glade culture or its predecessors are known from the area around Fisheating Creek. A number of sites with extensive earthworks have been found in the Belle Glade culture area. At least seven other sites in southern Florida, including two near Fisheating Creek, have similar circular features, although none of them has been subject to detailed examination by archaeologists. McGoun quotes Stephen Hale as saying that complexes "with sequences of construction and architectural style almost identical to those at Fort Center" are found from Lake Tohopekaliga in the north to Palm Beach and Hendry counties to the south. There are also similarities between Fort Center and the Crystal River site. Milanich also notes resemblances between Period II Fort Center and contemporary Cades Pond culture sites at River Styx and Cross Creek in northern Florida.