Fox Chase is a neighborhood in the Northeast section of Philadelphia, located approximately 10 mi (16 km) northeast of Center City. Although its borders are not officially defined, the neighborhood is generally bounded by Pennypack Park to the north, Algon Avenue to the east, Cottman Avenue to the south, and Fillmore Street to the west. Adjacent neighborhoods include Bustleton, Rhawnhurst, Burholme, and Rockledge (a borough in Montgomery County). Fox Chase uses the 19111 zip code.

Fox Chase was historically part of Lower Dublin Township, also known as Dublin Township, a defunct township located in Philadelphia County, Pennsylvania. The township ceased to exist and was incorporated into the City of Philadelphia following the passage of the Act of Consolidation, 1854.^{[citation needed]}

Philadelphia's elite once flocked to opulent vacation homes built in the lush fringes bordering the city. The area's character changed with the arrival of the railroad in 1876. Many of Philadelphia's aristocracy began to discover the attractiveness of suburban living, and built mansions here, using the railroad for convenient transport into the city.^{[citation needed]} The neighborhood was named after affluent colonists came to hunt in the region. A chase (land) is a specific area of land reserved for hunting.

Fox Chase was the setting for one of America's longest running cold cases. In February 1957, the battered body of a small boy was found in a cardboard box off in the woods off Susquehanna Road. Investigators were mystified and were unable to determine his identity. Nicknamed "The Boy in the Box", "America's Unknown Child", and sometimes "The Fox Chase Boy". He was identified as Joseph Augustus Zarelli in 2022.

The Fox Chase section is located on the border with Montgomery County and there is an active and cooperative business community that crosses the county line into Rockledge and Huntingdon Valley.

One of many parks located within Fox Chase is Pennypack Park. It is composed of woodlands, meadows and wetlands. The banks of the Pennypack Creek runs through the park from Pine Road in Fox Chase all the way to the Delaware River. The area also includes playgrounds, hiking and bike trails as well as bridle paths for horseback riding. The Pennypack Environmental Center on Verree Road is also located within the neighborhood. Many historic structures are still intact throughout Fox Chase. The Verree House on Verree Road was the site of a raid by British troops during the American Revolutionary War. The trained eye can rediscover abandoned railroad grades, remnants of early mills, mill races and other reminders that generations of mankind have gathered in the "Green Heart" of Northeast Philadelphia.

Fox Chase Farm is one of the few remaining active farms in Philadelphia County and is used extensively by the School District of Philadelphia. It began in 1683 as a land grant from William Penn to Lord Stanley and then passed to the McVeigh family for over 100 years. Later, the Wistar family developed it into a self-sufficient farm until it became a Gentlemen's Farm owned by two farmers, Lorimer and Butler. Friends of Fox Chase Farm, an all-volunteer group, currently assists in maintaining and preserving this pastoral treasure for present and future generations.

William Rhawn, president of the National Bank of the Republic in 1879, built a summer residence here. To design the project, he chose architect Frank Furness, whose work was synonymous with the mansions and public buildings of the Gilded Age. The banker's country estate includes a carriage house and gatekeeper's house. He called the estate “Knowlton” because it resembled the estate in England of Rhawn's wife's great-grandfather, John Knowles. It has since been converted into a catering establishment.