Francis Patrick Salemme (pronounced sah-LEM-ee; August 18, 1933 – December 13, 2022), sometimes spelled Salemmi, also known as "Cadillac Frank" and "the General", was an American mobster from Boston, Massachusetts who became a hitman and eventually the boss of the Patriarca crime family of New England before turning government witness.

Salemme was born on August 18, 1933, in Weymouth, Massachusetts, in the Greater Boston area, the second of six children of an Irish American mother, Mary Agnes (née Hagerty), a homemaker, and an Italian American father, Romeo Pasquale Salemme, a ship painter. His younger brother, John, also became a mobster. Salemme was raised in the Jamaica Plain neighborhood of Boston.

Salemme served in the U.S. Army during the Korean War and became a licensed electrician after receiving an honorable discharge. He married Alice Kathleen McLaughlin in Nashua, New Hampshire on November 16, 1955.

While in prison in 1957, Salemme became acquainted with Anthony Morelli, a member of the Patriarca crime family which controlled organized crime throughout New England. He began working for the family as a low-level associate after his release from prison. Salemme operated a number of semi-legitimate businesses such as automobile repair garages in partnership with George Kaufman, who served as the liaison between the Mafia and Boston's Jewish bookmakers. Salemme earned the nickname "Cadillac Frank" when he worked in an auto repair shop and specialized in repairing Cadillac automobiles.

Salemme began associating with a group of gangsters from Boston's Roxbury neighborhood, which included his childhood friend Stephen "the Rifleman" Flemmi. Salemme and Flemmi formed a partnership, and the duo became enforcers, bookmakers and loan sharks for the Patriarca family caporegime Ilario "Larry Baione" Zannino in the North End of Boston. Salemme grew so close to Flemmi that he named his son Stephen Salemme after him. Unknown to Salemme, however, Flemmi was a confidential informant for the Federal Bureau of Investigation (FBI) who provided the bureau with information on Salemme and others in the Patriarca family.

During the early 1960s, Salemme participated in the Irish gang wars in Boston, allying himself with the Winter Hill Gang against the Charlestown Gang. Testifying before Congress in 2003, Salemme admitted to murdering numerous rival gang members in Charlestown, Massachusetts:

The Hugheses, the McLaughlins, they were all eliminated, and I was a participant in just about all of them, planned them and did them.

In the summer of 1967, Zannino and Peter Limone decided to sponsor Salemme and Flemmi for membership in the Patriarca family. Although prospective members would ordinarily be required to carry out a murder in order to be inducted into the Mafia, the family offered to waive the requirement due to Salemme and Flemmi's reputation as seasoned killers. While Salemme was unequivocal in his enthusiasm for joining the Patriarca family, Flemmi had an ambivalent relationship with the Mafia. Salemme's partial Irish ancestry ultimately prevented him from becoming a "made man", however.