Fresh Air is an American radio talk show broadcast on National Public Radio stations across the United States since 1987. It is produced by WHYY-FM in Philadelphia, Pennsylvania, and hosted by Terry Gross and Tonya Mosley. The show is fed live weekdays at 12:00 noon ET, and some stations carry Fresh Air Weekend, a re-programming of highlights of the week's interviews. It won Peabody Awards in 1994 and 2022.

The show began in 1975 at WHYY (then called WUHY), with Judy Blank as host. In September of that year, Terry Gross took over as presenter and producer; nearly 50 years later she remains its chief presenter. In 1985, WHYY launched a weekly half-hour edition of Fresh Air, which was distributed nationally by NPR. The show began daily national broadcasts in 1987.

In February 2002, when host Gross interviewed Gene Simmons of Kiss, Simmons discussed his sexual experimentation with women of all age groups and propositioned Gross in demonstration; according to NPR's website, Simmons withheld permission to supply transcripts or audio of the interview on their website.

In July 2010, Fresh Air was removed from Mississippi Public Broadcasting radio because of "recurring inappropriate content", shortly after the broadcast of an interview with comedian Louis C.K. in which he discussed his sex life. By mid-2011, it had returned to the state network's evening line-up.

David Edelstein was sacked from his position as film critic for the show on November 27, 2018, for comments made in the wake of Bernardo Bertolucci's death.

Tonya Mosley, who co-hosted WBUR's Here & Now, was named co-host of Fresh Air in 2023. The show was formerly titled "Fresh Air with Terry Gross" but is now simply branded "Fresh Air".

Past contributors include Geoff Nunberg, Milo Miles, and Ed Ward.

Guests have included R.E.M.'s Michael Stipe.^{[citation needed]}