The Mitsubishi Fuso Truck and Bus Corporation (Japanese: 三菱ふそうトラック・バス株式会社, Hepburn: Mitsubishi Fusō Torakku・Basu Kabushiki gaisha) is a Japanese manufacturer of trucks and buses. It is headquartered in Kawasaki, Kanagawa and owned by Germany-based Daimler Truck.

Fuso derives from the ancient Chinese term fusang (扶桑), for a sacred tree said to grow at the spot in the east where the sun rises, and has been used to refer to Japan itself. The actual fuso tree is a hibiscus.

In 1932, the first B46 bus (the Fuso) was built at the Mitsubishi Shipbuilding Company's Kobe Works. Two years later (1934), the Mitsubishi Shipbuilding Company was renamed Mitsubishi Heavy Industries (MHI). Three years after that (1937), the MHI motor-vehicle operations at the Kobe Works were transferred to the Tokyo Works. In 1949, the Fuso Motors Sales Company was established.

In 1950, Mitsubishi Heavy Industries was split into three companies:

Two years later (1952):

Products from the companies were distributed by Mitsubishi Fuso Motor Sales because of brand recognition.

In 1957, MNHI integrated the Tokyo and Kawasaki Works into the Tokyo Motor Vehicle Works. Seven years later (1964), these three companies merged to form Mitsubishi Fuso Heavy Industries;

Mitsubishi Fuso Motors Sales split into two divisions: Shin and Fuso Motors Sales Company.