Fuzion is a generic role-playing game system created by the collaboration of R. Talsorian Games and Hero Games. The rights to Fuzion are jointly held by Mike Pondsmith of R. Talsorian Games, along with Steve Peterson and Ray Greer of Hero Games. Fuzion is a combination of the Interlock System, (used in games like Mekton and Cyberpunk 2020), and the HERO system (used in Champions, Justice, Inc., Star Hero, etc.). Fuzion is an adaptable system which can be played in any genre and setting imaginable.

Fuzion is noted for its anime-genre support, customizable rules flexibility, and was one of the first generic game systems to be released for free over the internet. It is one of the first games to readily allow licensing, albeit not the "hands-off" licensing offered by the Open Gaming License (OGL) that came about some years later. A modified OGL set of rules based on Fuzion is published by Gold Rush Games as the Action! System.

There are two published versions of Fuzion: the simplified Instant Fuzion, and more detailed Total Fuzion (also known as Primary Fuzion).

Fuzion uses a point-based creation method for building characters. This system is similar to both of the parent systems as well as other generic games like GURPS.

Fuzion characters are built with Character Points (CPs), also known as Stat Points. Depending on the "power level" of the game, the Referee (or Game Master), assigns players a number of CPs to buy Attribute Stats. Usually, 40 to 50 points are enough for a heroic "action-adventure" setting. Fewer points would be given for low-power games set in a more realistic, "mundane" world. A hundred (or more) points are given for high-powered, superheroic adventures. CPs are used to buy levels in Primary Stats which are the basic attribute abilities of the character.

Option Points (OPs), or Campaign Points, are given to characters to buy Character Options. OPs are assigned by the Referee and are usually kept separate from the Character Point pool. The Referee usually gives a pool of as many OPs as he gives CPs. At the player's choice, any leftover CPs not used to buy Stats can be traded for OPs at a ratio of 1:5, (1 CP = 5 OP) and vice versa. OPs can also be converted into money to buy Equipment at a ratio of 1:100; (1 OP = 100 units of currency). The actual type of currency is dependent upon the genre being played, (for instance a fantasy medieval-era game may use gold pieces, a modern action game set in the United States would use dollars, a sci-fi future setting may use galactic credits).

Certain campaigns using the Fuzion system can have Power Points (PPs), which are assigned to the players by the Referee just like CPs and OPs. PPs are optional and are used with Magic, Psionics, and Super Powers. CPs can be traded for PPs at a ratio of 1:1, (1 CP = 1 PP), and OPs can be traded as well, at a ratio of 5:1, (5 OP = 1 PP). Using PPs helps the Referee keep superpowers under control by restricting how often a character can use them.

In Total Fuzion, a character usually has ten Stats, (or Characteristics), organized in four groups as follows: