Galaxy High School (ギャラクシー・ハイスクール) is a science fiction animated series that premiered on September 13, 1986, on CBS and ran for 13 episodes until December 6, 1986. The series was created by Chris Columbus and featured music and a theme song composed by Don Felder.

Two Earth teenagers are accepted into the intergalactic high school Galaxy High School on the fictional asteroid Flutor. The teenage boy, Doyle Cleverlobe, was a skilled athlete and popular, while the teenage girl Aimee Brighttower was shy and, as the theme song states, "the smartest girl in school, not very popular, not very cool."

But once in space, their roles are somewhat reversed. The alien teenagers seem to accept the not-so-popular Aimee, while Doyle tends to rub the aliens the wrong way. Although Doyle finds himself an outcast and has difficulties adjusting, Aimee does not abandon him, and suggests he can make friends and bring glory to Galaxy High through his excellent sporting abilities, which he does by winning a championship in "psych-hockey", which Galaxy High had always lost in the past. The show drops many hints of a budding romance between Doyle and Aimee, but it was never given time to grow as the show was not renewed for a second season.

The aliens in the school include Gilda Gossip, the girl with a big mouth (or rather mouths), Booey Bubblehead, an absent-minded girl with a bubble for a head, Milo de Venus, the six-armed class president, Beef (a chicken-like alien) and the Bonk Bunch who bully Doyle (and just about every student at Galaxy High), and the Creep, a small alien resembling something between a fat cherub and a yellow marshmallow who has a huge crush on Aimee, which often revealed itself as he serenaded like a Las Vegas lounge singer. The teachers are even more unusual than the students: Ms. Biddy McBrain has a light bulb attached to her head, while Coach Frogface eats flies and Professor Icenstein has to keep his classroom cold to keep him from melting.

The animated series Partridge Family 2200 A.D., which debuted in 1974, features Keith and Laurie Partridge going to a futuristic space high school called "Galaxy High," and Laurie's friend Marion Moonglow (a Martian) bears a striking resemblance to the Wendy Garbo character from this series.

Galaxy High School was animated, distributed and owned by TMS Entertainment. TMS produced Galaxy High as an attempt to create a similar series to their hit Japanese anime show Urusei Yatsura (released 1981, based on a 1978 manga) for the American market. While Urusei Yatsura involves an alien girl attending a human high school, the school scenario in Galaxy High is reversed to be based around humans attending a high school for aliens.

John Kricfalusi was a character designer for the show and went on to create Ren & Stimpy and The Ripping Friends.

Syd Iwanter, the creative director, came up with the concept and hired Kricfalusi to draw a one-sheet pitch featuring the main characters for a proposed HIGH SCHOOL 2525. When Michael Chase Walker became director of children's programs for the CBS Television Network, he bought the show, changed the name to Galaxy High School and convinced up-and-coming screenwriter turned future filmmaker Chris Columbus to develop the show under his name. Walker was trying to develop a Saturday morning schedule that resembled an old-fashioned Saturday movie matinée with a range of horror (Teen Wolf), science fiction (Galaxy High School), comedy (Pee-wee's Playhouse) and Western (Wildfire).