Galileo Academy of Science and Technology, formerly known as Galileo High School, is a public high school located in the northeastern corner of the Russian Hill neighborhood, near the Marina District and Fisherman's Wharf neighborhoods of San Francisco, California. The school is a part of the San Francisco Unified School District.

Galileo Academy is located in the historic north end of San Francisco, and was originally built in 1921. As of May 2015, Galileo has more than 150 faculty and staff members and serves more than 1,800 students. It is one of two Bay Area schools with an observatory. The observatory at Galileo is not in use at this time. Plans for restoration are in progress. Galileo received the 2005 California Distinguished School Award along with the 2005 CTE Award - one of the very few schools that were awarded this.

The lion is the official mascot of Galileo. In sports and other inter-school activities the team members are known as the Galileo Lions. The official school colors are purple and orange. Galileo has an internal television network, G-House TV, which is broadcast by students of the Media Arts Pathway. The Media Arts Pathway (MAP) works on all media-related works while AoIT concentrates on computer science related works. The school motto is Eppure si muove (Italian: And yet it moves). As the story goes, Galileo Galilei was told to deny his scientific findings that the earth moved, or be punished - so he did as he was ordered. But on his way out he mumbled to himself, "And yet it moves."

On December 10, 1920, Major Joseph P. Nourse, who had been actively engaged in educational work in the city for many years, became the first principal of Galileo High School. Throughout the summer, carpenters were busy converting the Red Cross Building, located on Fulton Street near the Civic Center. On August 1, 1921, Galileo High School welcomed its student body into the remodeled facilities. The ceremony of "breaking ground" for the new building was on November 4, 1921, and the dedication of the Van Ness Building on March 30, 1924. At the same time, plans were underway for a new wing which would double the school's capacity.

In the 1920s, the Galileo High School building was considered an outstanding example of modern architecture. Planned with the intention of housing one of the best educational institutions in the country, it was equipped to offer the highest type of academic curriculum in addition to training in commercial and technical branches.

During the 1970s, Galileo went through an extensive refit where most, if not all, student facilities were moved across the street onto Fort Mason. Before this, there were rumors that the Galileo campus would be permanently moved onto the Fort Mason site. Though the student population, then, did not indicate whether the move and larger facilities would be justified, the land that Galileo sits on was quite valuable, which could have made the move plausible.

Since the 1995-96 school year, Galileo has transformed itself to the Galileo Academy of Science and Technology. The new program provides students with career pathways and academies. These include the Galileo Health Academy, the Academy of Information Technology (AoIT), Biotechnology Pathway and the Environmental Science Pathway. In 2006-2007, the Publications Pathway was introduced and, in 2007-2008, the Academy of Hospitality and Tourism (AoHT) and Digital Photography Pathway.

On September 25, 2007, while some construction workers were digging the courtyard, they found a time capsule which was thought to be lost forever by the Class of 1982. It was uncovered that day, but was filled with water, as well as a yearbook, a frisbee, a Rubik's Cube and a Mighty Lion T-shirt. It was buried shortly after the class of '82 graduated, but, in 1997, a search for the time capsule over every square foot of the courtyard turned up nothing. The time capsule is now stored in one of the closets in the building.