Gladstone Region is a local government area in Queensland, Australia. The council covers an area of 10,484 square kilometres (4,048 sq mi), and has an estimated operating budget of A$84 million.

In the 2021 census, the Gladstone Region had a population of 63,515 people.

Gladstone Region came into being on 15 March 2008 as a result of the report of the Local Government Reform Commission released in July 2007. The legal standing of the council is sourced from the Local Government Reform Act 2007 (Qld). The Gladstone Region was named after William Ewart Gladstone, British Chancellor of the Exchequer and he later became prime minister.

The new Council, located in Central Queensland, contains the entire area of three former local government areas:

The report recommended that the new local government area should not be divided into wards and elect eight councillors and a mayor.

In the 2016 census, the Gladstone Region had a population of 61,640 people.

In the 2021 census, the Gladstone Region had a population of 63,515 people.

The first mayor of the Gladstone Regional Council was George Creed, who had been the mayor of the Calliope Shire Council. Creed retired due to ill-health in September 2010, and died November 2010. He was succeeded by Gail Sellers. The mayor since March 2016 is Matthew James (Matt) Burnett.