The Great Central Railway in England was formed when the Manchester, Sheffield and Lincolnshire Railway changed its name in 1897, anticipating the opening in 1899 of its London Extension. On 1 January 1923, the company was grouped into the London and North Eastern Railway.

On assuming its new title, the Great Central Railway had a main line from Manchester London Road Station via Penistone, Sheffield Victoria, Brigg and Grimsby to Cleethorpes. A second line left the line at Penistone and served Barnsley, Doncaster and Scunthorpe, before rejoining the Grimsby line at Barnetby. Other lines linked Sheffield to Barnsley (via Chapeltown) and Doncaster (via Rotherham) and also Lincoln and Wrawby Junction. Branch lines in north Lincolnshire ran to Barton-upon-Humber and New Holland and served ironstone quarries in the Scunthorpe area. In the Manchester area, lines ran to Stalybridge and Glossop.

In the 1890s, the MS&LR began constructing its Derbyshire lines, the first part of its push southwards. Leaving its east–west main line at Woodhouse Junction, some 5½ miles south-east of Sheffield, the line headed towards Nottingham, a golden opportunity to tap into colliery traffic in the north of the county before reaching the city. A loop line was built to serve its station in Chesterfield.

The Great Central Railway was the first railway granted a coat of arms. It was granted on 25 February 1898 by the Garter, Clarenceux and Norroy Kings of Arms as:

Argent on a cross gules voided of the field between two wings in chief sable and as many daggers erect, in base of the second, in the fesse point a morion winged of the third, on a chief also of the second a pale of the first thereon eight arrows saltirewise banded also of the third, between on the dexter side three bendlets enhanced and on the sinister a fleur de lis or. And for the Crest on a Wreath of the Colours A representation of the front of a locomotive engine between two wings Or as the same are in the margin hereof more plainly depicted to be borne and used for ever hereafter by the said Corporation of the Great Central Railway Company on seals, shields, banners or otherwise according to the Laws of Arms.

The design included elements representing Manchester (gules ... three bendlets enhanced ... or); Sheffield (eight arrows saltirewise banded); Lincoln (gules ... a fleur de lis or); Leicester (two wings); and London (Argent ... a cross gules ... daggers erect). Also represented was Mercury (a morion winged [sable]). It was used on locomotives and coaches.

The London and North Eastern Railway and the British Transport Commission, successors of the GCR, were granted arms of their own incorporating the GCR motto Forward.

The Great Central Railway (1976) Company Limited applied to the College of Arms as the successors to British Transport Commission (Loughborough to Birstall Light Railway) for permission to utilise the coat of arms of the GCR. A new design incorporating the same armorial components, updated in the modern style was proposed, but was rejected in favour of the original.^{[citation needed]}