The Greater Seattle Business Association (GSBA) is an LGBTQ+ chamber of commerce based in Seattle, Washington. The majority of the organization's membership are small businesses located throughout the Puget Sound area. The association's stated mission is "to combine business development, leadership and social action to expand economic opportunities for the lesbian, gay, bisexual, transgender, and queer community and those who support equality for all."

GSBA was stablished in 1981. It represents over 1,300 small business, corporate, and nonprofit members.

In 1992, GSBA formed the Western Business Alliance in partnership with the Greater San Diego Business Association and the Camelback Business Association of Phoenix. In 1997, the WBA brought together 21 LGBT-and-allied organizations—from Vancouver, British Columbia, in the north, to Tijuana, Mexico, in the south. With the establishment of the National Gay & Lesbian Chamber of Commerce in 2004 (of which GSBA was a founding member), GSBA's current executive director, Louise Chernin, was appointed National Chair on the Council on Chambers and Business Organizations (CCBO), a position she held for four years. The following year, the WBA voted in favor of folding into the NGLCC's CCBO structure as the Pacific Regional Council.

GSBA was the presenting sponsor of the first Gay Wedding Show in 2004. Held at Seattle's Swedish Cultural Center, the event hosted 50 vendors and was the first of its kind in Seattle.

In November 2008, GSBA was awarded "Chamber of the Year" by the National Gay & Lesbian Chamber of Commerce (NGLCC) in Washington, D.C., recognizing its leadership among more than 45 other regional LGBT and allied chambers. In 2009, GSBA was the host affiliate chamber for NGLCC's Sixth Annual Out for Business Conference, held in Seattle. That year, GSBA received the "Community Outreach Award" for its scholarship program.

In 2006, when efforts were undertaken to repeal Washington's non-discrimination law through public referendum, GSBA stood alongside other organizations in support of Washington Won't Discriminate, a group opposing the referendum. In 2009, enough signatures were obtained by put Referendum 71 on that year's general election ballot. This referendum would have overturned the state's third and final expansion of domestic partnership law passed by the legislature earlier that year. GSBA was among 282 coalition partners of Washington Families Standing Together, the organization that led the campaign to approve Referendum 71.

Every September, the organization holds a debate-like program, the GSBA Candidate Forum. The event is billed as "the region's only LGBT candidate forum". The forum has featured candidates from local races such as city and county councils as well as larger offices including Washington Governor and U.S. House of Representatives.

In 2009, then mayoral candidate Mike McGinn was criticized for his "rude" treatment of GSBA staff members while attending that year's event. Subsequently, he won the 2009 election.