Greenspring Avenue is a road in Baltimore, Maryland and its northwestern suburbs. At one time, Greenspring Avenue was Maryland Route 519 from Worthington Road to Dover Road, but the road has since been decommissioned and no longer has any numerical designation.

Greenspring Avenue is currently divided into three sections, as follows:

Greenspring Avenue begins inside of Druid Hill Park, near the Maryland Zoo. The first section, which is approximately 1.9 miles (3.1 km) long, is mostly lined with high-rise and garden apartments. This section ends at Northern Parkway, at Sinai Hospital, and across from Cylburn Park. From here, a left and then a right two blocks later is required to continue along Greenspring.

The next section of Greenspring Avenue starts off of Northern Parkway about one block west of Sinai Hospital, and continues for about 3/4 of a mile to a five-way intersection consisting of Cross Country Boulevard and Pimlico Road, in an area known as Cheswolde. A right turn is required here to continue along Greenspring.

The third and longest section of Greenspring Avenue continues from this intersection for about 10 miles (16 km) until the end of the name Greenspring Avenue for the road. However, the road physically continues beyond this point and is known as Worthington Avenue for the next mile and a half.

It finally continues into Butler Road (Maryland Route 128) before it reaches Hanover Pike (Maryland Route 30), at which point going straight will lead to I-795. This section of the road can be accessed from the Baltimore Beltway at exit 22.

The Green Spring Avenue Company was chartered in 1858 to build the portion south of Maryland Route 130 as a turnpike.

Throughout the 2000s, construction has been underway for a new development now known as Quarry Lake at Greenspring, which is located between Old Court Road and Smith Avenue.