Guilherme Antonio Arana Lopes (born 14 April 1997), known as Guilherme Arana, is a Brazilian professional footballer who plays as a left-back for Campeonato Brasileiro Série A club Atlético Mineiro and the Brazil national team.

Born in São Paulo, Arana was a part of Corinthians youth squads for many years, being considered one of the top prospects of the club. He won the 2014 U20 Campeonato Paulista, 2014 U20 Campeonato Brasileiro and 2015 Copa São Paulo de Futebol Júnior, also being a runner-up at the 2014 edition.

Arana was promoted to Corinthians' main squad after the 2014 Copa São Paulo de Futebol Júnior final and was an unused substitute in twelve matches of the 2014 Campeonato Brasileiro Série A.

Arana was part of the main squad for the 2015 Campeonato Paulista and 2015 Copa Libertadores.

Arana was loaned to Atlético Paranaense on 7 May 2015 for the remaining of the year as part of the squad for the 2015 Campeonato Brasileiro Série A. He made his professional debut as a substitute against Atlético Mineiro on 24 May. He was called back by Corinthians on 26 June.

On 12 August 2015, Arana made his Corinthians debut as a substitute during half-time in a 4–3 win against Sport Recife at Arena Corinthians. He was directly responsible for the second goal of Sport, as he made a wrong pass that was intercepted and resulted in a goal. He compensated for the mistake by creating the opportunity that resulted in a penalty kick, which gave Corinthians the victory. He made his first league start in the away game against Avaí on 16 August. On 6 September, Arana scored his first goal in a 3–3 away draw against Corinthians' biggest rival Palmeiras.

On 7 December 2017, Arana transferred to Spanish club Sevilla on a deal worth 12 million euros and signed a four-and-a-half-year contract. He joined the squad upon the opening of the winter transfer window in January 2018.

On 28 August 2019, Arana joined Italian club Atalanta on a season-long loan with the option to buy.