Guillaume Emmanuel "Guy-Manuel" de Homem-Christo (French pronunciation: [ɡi(jom e)manɥɛl də ɔmɛm kʁisto]; born 8 February 1974) is a French musician, record producer, disc jockey, singer-songwriter and composer. He is known as one half of the former French house music duo Daft Punk, along with Thomas Bangalter. He has produced several works from his now-defunct record label Crydamoure with label co-owner Éric Chedeville.

Guillaume Emmanuel de Homem-Christo was born on 8 February 1974 in Neuilly-sur-Seine, Hauts-de-Seine. He is the great-grandson of Portuguese poet Homem Cristo Filho [pt], as well as the great-great-grandson of Portuguese military figure Francisco Manuel Homem Cristo, who was forced into exile in France in 1910.

He was given a toy guitar and keyboard at around age 7. He was also given an electric guitar at age 14; he still uses a guitar when writing music.

Homem-Christo met Thomas Bangalter when they attended the Lycée Carnot in Paris in 1987. It was there that they discovered their mutual fascination for films and music of the 1960s and 1970s: "very basic cult teenager things, from Easy Rider to the Velvet Underground". The two and Laurent Brancowitz eventually joined to form an indie rock trio called Darlin', in which Homem-Christo performed guitar. Bangalter felt that "It was still maybe more a teenage thing at that time. It's like, you know, everybody wants to be in a band." A negative review referred to their music as "a daft punky thrash", which inspired Bangalter and Homem-Christo's new name. The two soon became interested in electronic dance music after going to a club in 1992. Homem-Christo is credited for designing the Daft Punk logo in the liner notes of Homework (1997), the duo's first album.

Regarding Daft Punk's creative process and working with Bangalter, Homem-Christo commented that "he's much more of the tech guy than I am. We did everything together. But I have more distance". He added, "I'm more critical of everything we do. We're two-halves of one solid combination. There's balance there – completeness between us, yeah".

Homem-Christo is a co-founder of the group Le Knight Club, along with Éric Chedeville from Pumpking Records. They are the founders of the record label Crydamoure, named after a variation of the French phrase "cri d'amour" or "cry of love" in English. Crydamoure published works by Homem-Christo's brother Paul, under the name Play Paul. They also published records by Deelat, Raw Man, The Eternals, and many others. In regards to Crydamoure, Homem-Christo stated:

Myself and Thomas have the same tastes in music. When I make records for Crydamoure it's a different style than what may end up as Daft Punk music. I know what Thomas likes, and he knows what I like. Crydamoure is not so production oriented, even if it's not too far from Daft Punk. The Daft Punk material is more orchestrated and slightly different. I may be working on a sample for Crydamoure, and maybe no one else can hear the difference, but we know. It's very precise.

Daft Punk produced three projects in the 2000s, their sophomore album Discovery (2001), their third album Human After All (2005), and the soundtrack to TRON: Legacy (2010). The duo also did a world tour in 2006 and 2007, eventually releasing an accompanying live album, Alive 2007.