The Guye (French pronunciation: [ɡi]) is a 46.6-kilometre (29.0 mi) long river in the Saône-et-Loire département, central eastern France. It flows primarily south, before turning east-northeast near Salornay-sur-Guye and flowing into the Grosne. It is a left tributary of the Grosne into which it flows between Malay and Savigny-sur-Grosne.

The following communes, ordered from source to mouth, lie along the Guye: