Homeobox protein Hox-B2 is a protein that in humans is encoded by the HOXB2 gene.

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with pancreatic cancer.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.