Handsworth (grid reference SP035905) is an inner-city area of Birmingham in the county of the West Midlands, England. Historically in Staffordshire, Handsworth lies just outside Birmingham City Centre and near the town of Smethwick. In 2021 the ward had a population of 11,820.

The name Handsworth originates from its Saxon owner Hondes and the Old English word weorthing, meaning farm or estate. It was recorded in the Domesday Survey of 1086, as a holding of William Fitz-Ansculf, the Lord of Dudley, although at that time it would only have been a very small village surrounded by farmland and extensive woodland. One of the oldest buildings in Handsworth is the Old Town Hall which dates from 1460.

Historically in the county of Staffordshire, it remained a small village from the 13th century to the 18th century. Accommodation was built for factory workers, the village quickly grew, and in 1851, more than 6,000 people were living in the township. In that year, work began to build St James' Church. Later St Michael's Church was built as a daughter church to St James'. In the census of 1881, the town was recorded as having approx. 32,000 residents. By the census of 1911, this had more than doubled to 68,610. The Council House, in Soho Road, now used as a public library and college campus, was completed in 1879.

The development of the built environment was sporadic and many of Handsworth's streets display a mixture of architectural types and periods – among them some of the finest Victorian buildings in the city. Handsworth has two grammar schools – Handsworth Grammar School and King Edward VI Handsworth School (for girls). St Andrew's Church is a listed building in Oxhill Road which also held Sunday school classes in a small building on the corner of Oxhill Road and Church Lane. It also contains Handsworth Park, which in 2006 underwent a major restoration, the vibrant shopping area of Soho Road and St. Mary's Church containing the remains of the founders of the Industrial Revolution - Watt, Murdoch and Boulton. The 1901 Red Lion public house was grade II* listed in 1985, but has been empty since 2008 and is considered "at risk".

In 1894 Handsworth became an urban district, on 9 November 1911 the urban district was abolished and merged with the County Borough of Birmingham and Handsworth parish was transferred from Staffordshire to Warwickshire. In 1921 the civil parish had a population of 75,145. On 1 October 1930 the parish was abolished and merged with Birmingham.

Birmingham historian Dr. Carl Chinn noted that during the Second World War the boundary between Handsworth and the outlying suburb of Handsworth Wood marked the line between being safe and unsafe from bombing, with Handsworth Wood being an official evacuation zone, despite being at least ten miles away from any countryside that might now qualify as "green belt" land, and being on the periphery of many "high risk" areas. During the Second World War, West Indians had arrived as part of the colonial war effort, where they worked in Birmingham munitions factories. In the post-war period, a rebuilding programme required much unskilled labour and Birmingham's industrial base expanded, significantly increasing the demand for both skilled and unskilled workers. During this time, there was direct recruitment for workers from the Caribbean and the area became a centre for Birmingham's Afro-Caribbean community.

A tram depot was erected near Birmingham Road, next to the border with West Bromwich, during the 1880s, and remained in use until the tram service ended in 1939. Although it has since been demolished, a replica of the depot was created later in the 20th century at the Black Country Living Museum in Dudley.

Matthew Boulton's Soho Manufactory was set up on the northern edge of Handsworth, on Handsworth Heath. It operated from 1766 to 1848, and was demolished in 1863. Boulton commissioned Samuel Wyatt to design his nearby house Soho House, which is now a museum.