Harpurhey (/ˈhɑːrpərˌheɪ/ HAR-pər-HAY) is an inner-city suburb of Manchester, England, 2.3 miles (3.7 km) northeast of the city centre. Historically in Lancashire, the population at the 2011 census was 17,652.

Areas of Harpurhey include Kingsbridge Estate, Barnes Green, Shiredale Estate and Baywood Estate.

Harpurhey is recorded in 1320 as "Harpourhey", meaning "hedged enclosure by a man called Harpour", who owned the area in the 14th century.

Harpurhey lies on both sides of Rochdale Road from Collyhurst to Blackley, extending westward to the Irk. In 1830, it was described as abounding in pleasant views, but by 2007 was characterised as the worst place in England.

Harpurhey was formerly a township and chapelry in the parish of Manchester, in 1866 Harpurhey became a separate civil parish. Harpurhey was included in the parliamentary borough of Manchester from its creation but was not taken into the municipal borough until 1885. On 26 March 1896 the parish was abolished to form North Manchester. In 1891 the parish had a population of 8380. Harpurhey is one of the most economically deprived areas within the Greater Manchester area.

Harpurhey is within the Blackley and Middleton South constituency, which has been represented in the House of Commons by Labour MP Graham Stringer who was first elected to the old Manchester Blackley constituency in 1997 and represented Blackley and Broughton from its creation in 2010 to its abolition in 2024. Before his election to Parliament, he was a councillor for Harpurhey from 1982, and leader of Manchester City Council from 1984.

The ward is represented on Manchester City Council by three Labour Party councillors: Pat Karney (Lab), Joanne Green (Lab) and Sandra Collins (Lab).

  indicates seat up for re-election.