Hartlepool nuclear power station is a nuclear power station situated on the northern bank of the mouth of the River Tees, 2.5 mi (4 kilometres) south of Hartlepool in County Durham, North East England. The station has a net electrical output of 1,185 megawatts, which is 2% of Great Britain's peak electricity demand of 60 GW. Electricity is produced through the use of two advanced gas-cooled reactors (AGR). Hartlepool was only the third nuclear power station in the United Kingdom to use AGR technology. It was also the first nuclear power station to be built close to a major urban area.

Originally planned in 1967, with construction starting in 1969, the station started generating electricity in 1983 and was completed in 1985, initially being operated by the Central Electricity Generating Board. With privatisation of the UK's electric supply industry in 1990, the station has been owned by Nuclear Electric and British Energy but is now owned and operated by EDF Energy.

The power station will cease power generation in March 2028, prior to defuelling and decommissioning.

After building the first operational advanced gas-cooled reactor (AGR) nuclear power station at Dungeness, the Central Electricity Generating Board (CEGB) proposed that their third AGR station in 1967 be situated on the edge of the Durham coalfield, near the seaside resort of Seaton Carew. The proposal came at a time when the CEGB's move toward fuels alternative to coal threatened the existence of the coal industry. Despite that, and a short ministerial delay, the plans for the Seaton Carew station (which became known as Hartlepool nuclear power station) went ahead. Because the construction of the station was given the go ahead, the National Coal Board were not able to get the CEGB behind the plans for a prototype fluidised bed combustion (FBC) coal station at Grimethorpe in Yorkshire. Because of that the UK did not build FBC technology.

Sited 1.65 mi (2.66 km) from Seaton Carew and in the middle of the industrial complex of Teesside, the station was to be built closer to any major urban area than any nuclear power station site had been. To make that acceptable, the station's reactors were to be housed in pressure vessels made from prestressed concrete.

The construction of the power station, which was undertaken by Nuclear Design & Construction ('NDC'), a consortium backed by English Electric, Babcock International Group and Taylor Woodrow Construction, began in 1969.

Construction was delayed in 1970, when the Nuclear Installations Inspectorate declared that they were unhappy with part of the station's boiler design, setting the CEGB back £25 million. The station's reactors were supplied by the National Nuclear Corporation, and its generating sets by the General Electric Company. The first of the station's two units were commissioned in 1983, the other in 1985. The station first generated electricity commercially on 1 August 1983.

Nuclear fuel for Hartlepool power station is delivered and removed via a loading/unloading facility on a 1.5-mile (2.4 km) branch from the Durham Coast Line.