David Hayter voiced Solid Snake and Naked Snake in the English versions of the Metal Gear Solid series, becoming synonymous with the character for many fans.

The Metal Gear Solid series featured strong performances from its Japanese voice cast, including Akio Ōtsuka as Solid Snake and Kikuko Inoue as Rosemary.

Norman Reedus stars as Sam Porter Bridges in Death Stranding. His performance is central to the game's narrative and emotional impact.

Mads Mikkelsen portrays Cliff Unger in Death Stranding, delivering a compelling performance as a complex and tormented character.

Léa Seydoux plays Fragile in Death Stranding. Her character's story and performance add depth to the game's themes of connection and vulnerability.

Guillermo del Toro's likeness is used for the character Deadman in Death Stranding. His inclusion is a nod to the friendship and creative partnership between Kojima and del Toro.

Nicolas Winding Refn appears as Heartman in Death Stranding, adding another layer of directorial talent to the game's ensemble cast.