His Eminence (abbreviated H.Em. or HE) is a style of reference for high nobility, still in use in various religious contexts.

The style remains in use as the official style or standard form of address in reference to a cardinal of the Catholic Church, reflecting his status as a Prince of the Church.

A longer, and more formal, title is "His [or Your when addressing the cardinal directly] Most Reverend Eminence".

Patriarchs of Eastern Catholic Churches who are also cardinals may be addressed as "His Eminence" or by the style particular to Catholic patriarchs, His Beatitude.

In 1630, the Grand Master of the Sovereign Military Order of Malta was awarded the hybrid style His Most Eminent Highness (abbreviation HMEH) to recognize his status as a type of Prince of the Church, by precedence the most senior official after the most junior member of the cardinals. He had already been made a Reichsfürst (i.e., prince of the Holy Roman Empire) in 1607.

The Prince and Grand Master of the contemporary Sovereign Military Order of Malta is still styled His Most Eminent Highness. Styles such as "His Grand Eminence" or "His Eminent Grace" amongst others were used as well, some formalized by the Pope or other powers, such as monarchs. However, many others were simply the personal preference of the cardinal and by the merit of other earthly offices.

While the term is shunned by many individuals of other faiths or denominations of Christianity, the title is officially maintained in international diplomacy without regard for its doctrinal, philosophical and theological origins.

Archbishops under the Ecumenical Patriarchate (those who are not the primates of autocephalous churches) and metropolitans in the Eastern Orthodox Church are addressed with the style of "Eminence". Archbishops of independent churches are addressed with the style of "Beatitude". Titular metropolitans are addressed with the style of "Excellency".