Holy Cross College is a private Catholic college in Notre Dame, Indiana, United States. The college was founded by members of the Congregation of Holy Cross in 1966.

Holy Cross College was initially established in 1966 by the Mid-West Province of the Brothers of the Holy Cross as a two-year junior college, primarily to educate Holy Cross Brothers. Lay male students from the surrounding area started enrolling in 1967 and the college became coeducational in the fall of 1968. The first president and dean was John Driscoll, C.S.C. Originally, Holy Cross College only offered a two-year degree, and students would then go on to top tier institutions like Notre Dame, Purdue, or Princeton. Over time, Holy Cross College increased its enrollment and academic offerings, and started to offer four year bachelor's degree and many students would complete their education there and the institution became a destination in its own right. In 2013, the college received a record donation of $2 million from Guy Gundlach and the Elkhart County Community Foundation, aimed at providing scholarships to family and spouses of fallen veterans. David Tyson became president in 2017 and set to repair the school's finances and reorganize the school. Due to a land sale to the University of Notre Dame and a reorganization of the curriculum, the college saw its financial situation improve and its enrollment increase. Under his direction, the school reinstated the two-year program aimed at students wishing to transfer to other schools like Notre Dame, as well as a three-year program for highly motivated students, in addition to new faculty hires. In 2020, it received a $1 million grant from the Lilly Endowment Inc. through the Charting the Future of Indiana's Colleges and Universities program.

The college's baccalaureate program focuses on experiential learning, founded upon a program of Four Pillars: Service Learning, Global Perspectives, Professional Internship, Classroom Experience which culminates in a capstone presentation. Each student completes the same multidisciplinary core courses. Electives may be taken which allows each student to gain knowledge and experience preferred areas of interest. Students have faculty advisors for each major and minor they are pursuing. Students may take courses at any of the local universities participating in the Northern Indiana Consortium for Education (NICE). After amassing 30 credit hours (typically after the first year of studies), students may take classes at the University of Notre Dame at no extra cost, provided they maintain at least a 3.0 grade point average.

Current accreditation at the Baccalaureate level includes ten Bachelor of Arts degrees, 17 minors, and two Bachelor of Science degrees in Biology and Computer Science. As of 2018, Business, Psychology, and Communications were the most popular major, although History and Liberal Arts have received favorable reviews. The student-faculty ratio is 12:1, and 93.4% of classes have fewer than 20 students.

For 2022, was ranked 23rd in Regional Colleges Midwest, 27th in Best Value Schools, and 13th in Top Performers on Social Mobility by U.S. News & World Report.

Students take part in the about 500 student clubs and organizations across the tri-campus community, including Notre Dame and Saint Mary's College (Indiana). The college's intramural sports, include flag football, volleyball, basketball, and pickleball. Holy Cross hosts its Student Government, which is composed of the Executive Board, the Programming Board, and the Student Senate. The Social Concerns Committee plays an important role in the student's body volunteering and social service causes. Holy Cross students can be members of the University of Notre Dame Marching Band.

Holy Cross has six residence halls for students: four male residence halls and two female residence halls. The six residence halls are: Anselm, Basil, James, North, Pulte, and South. Anselm Hall and Basil Hall are traditional male dorms, James Hall and North Hall are traditional female dorms, and Pulte Hall and South hall are apartment-style male dorms.

In addition to the residence halls on campus, upperclassmen are allowed to live off-campus in a co-ed apartment complex called University Edge, located roughly one mile north of Holy Cross.