How to Change Your Mind: What the New Science of Psychedelics Teaches Us About Consciousness, Dying, Addiction, Depression, and Transcendence is a 2018 book by Michael Pollan. It became a No. 1 New York Times best-seller. How to Change Your Mind chronicles the history of psychedelic drugs, from their turbulent 1960s heyday to the resulting backlash and more recent revival. Through his coverage of the recent resurgence in this field of research, as well as his own personal use of psychedelics via a "mental travelogue", Pollan seeks to illuminate not only the mechanics of the drugs themselves, but also the inner workings of the human mind and consciousness.

The book received many positive reviews, and Netflix released a documentary based upon it in 2022.

The book is organized into six chapters with an epilogue:

Pollan has been interviewed concerning the book on popular podcasts such as The Tim Ferriss Show, The Kevin Rose Show and The Joe Rogan Experience.

The New York Times Book Review named How to Change Your Mind one of the best books of 2018.

Kevin Canfield of the San Francisco Chronicle wrote: "In 'How to Change Your Mind', Pollan explores the circuitous history of these often-misunderstood substances, and reports on the clinical trials that suggest psychedelics can help with depression, addiction and the angst that accompanies terminal illnesses. He does so in the breezy prose that has turned his previous books – these include The Omnivore's Dilemma and Cooked, the inspiration for his winning Netflix documentaries of the same name – into bestsellers."

Jacob Sullum of the libertarian magazine Reason gave the book a generally positive review, but faulted Pollan for criticizing Timothy Leary's self-promotion without allocating blame to the politicians and journalists who shut down the promising scientific study of psychedelics.

Writing in New York magazine, conservative journalist Andrew Sullivan praised How to Change Your Mind as "astounding."