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Hp53int1
Human protein 53 intron 1 (Hp53int1) is a protein encoded by the Hp53int1 gene in humans.
The Hp53int1 gene is located on chromosome 17p.13, encoded by a DNA sequence 1125 base pairs in length, covering region 7,685,260 bp-7,686,371 bp. The Hp53int1 gene has two aliases, WRAP53int1 and TP53int1, in accordance to its overlap with the WRAP53 and TP53int1 genes on chromosome 17. Hp53int1 is located downstream of the p53p2 start site.
Hp53int1 does not have multiple exons, and therefore has no isoforms.
The Hp53int1 gene is transcribed in the same direction as TP53 and is present in TP53 protein-rich myeloid leukemia cells HL-60 and U937. This suggests a strong relationship to the TP53 gene and subsequent protein, including a share of transcription factors, promoter signals, tissue expression, and subcellular localization. While these genes are not identical, this relationship may give clues to function, structure, and expression.
Hp53int1 is encoded by a polyadenylated transcript 1125 base pairs in length. There is a repeat sequence between base pairs 633...926 and a regulatory Poly A tail sequence between base pairs 496...1000. The repeat sequence between base pairs 633 and 926 is noted to be similar to the Alu SC subfamily repeat, a sequence that characterizes the most abundant repeat sequences in humans and primates, and which likely diverged from other Alu subfamily complexes around 32 million years ago.
The promoter sequence of the Hp53int1 gene was shown to be 540 base pairs in length. Transcription factors SMAD2, SRY, and ETV7 had Basewise Conservation Scores of 2.99, 2.73, and 3.03 respectively, with value of 4 indicating the highest conservation and -0.5 the lowest. KLF2 and KLF5 had scores of 3.73 each. The species being compared were elephant, dog, rhesus macaque, and chicken.
The Hp53int1 protein has a molecular weight of 13.3 kdal and is 118 amino acids in length. It is a basic protein. There is one highly conserved amino acid sequence between 102 and 110. Serine site distribution is significantly higher than Arginine and Tyrosine sites. There is a possible Casein Kinase II phosphorylation site between amino acids 22–25. Casein Kinase II phosphorylation is involved in cell proliferation. Three regions of disorder are predicted for the Hp53int1 protein.
There is a possible O-ß-GlcNAc site between amino acids 14–20. There are no transmembrane domains nor signal peptides.
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Hp53int1
Human protein 53 intron 1 (Hp53int1) is a protein encoded by the Hp53int1 gene in humans.
The Hp53int1 gene is located on chromosome 17p.13, encoded by a DNA sequence 1125 base pairs in length, covering region 7,685,260 bp-7,686,371 bp. The Hp53int1 gene has two aliases, WRAP53int1 and TP53int1, in accordance to its overlap with the WRAP53 and TP53int1 genes on chromosome 17. Hp53int1 is located downstream of the p53p2 start site.
Hp53int1 does not have multiple exons, and therefore has no isoforms.
The Hp53int1 gene is transcribed in the same direction as TP53 and is present in TP53 protein-rich myeloid leukemia cells HL-60 and U937. This suggests a strong relationship to the TP53 gene and subsequent protein, including a share of transcription factors, promoter signals, tissue expression, and subcellular localization. While these genes are not identical, this relationship may give clues to function, structure, and expression.
Hp53int1 is encoded by a polyadenylated transcript 1125 base pairs in length. There is a repeat sequence between base pairs 633...926 and a regulatory Poly A tail sequence between base pairs 496...1000. The repeat sequence between base pairs 633 and 926 is noted to be similar to the Alu SC subfamily repeat, a sequence that characterizes the most abundant repeat sequences in humans and primates, and which likely diverged from other Alu subfamily complexes around 32 million years ago.
The promoter sequence of the Hp53int1 gene was shown to be 540 base pairs in length. Transcription factors SMAD2, SRY, and ETV7 had Basewise Conservation Scores of 2.99, 2.73, and 3.03 respectively, with value of 4 indicating the highest conservation and -0.5 the lowest. KLF2 and KLF5 had scores of 3.73 each. The species being compared were elephant, dog, rhesus macaque, and chicken.
The Hp53int1 protein has a molecular weight of 13.3 kdal and is 118 amino acids in length. It is a basic protein. There is one highly conserved amino acid sequence between 102 and 110. Serine site distribution is significantly higher than Arginine and Tyrosine sites. There is a possible Casein Kinase II phosphorylation site between amino acids 22–25. Casein Kinase II phosphorylation is involved in cell proliferation. Three regions of disorder are predicted for the Hp53int1 protein.
There is a possible O-ß-GlcNAc site between amino acids 14–20. There are no transmembrane domains nor signal peptides.