Human reproduction

Human sexual reproduction, to produce offspring, begins with fertilization. Successful reproduction typically involves sexual intercourse between a healthy, sexually mature and fertile male and female. During sexual intercourse, sperm cells are ejaculated into the vagina through the penis, resulting in fertilization of an ovum to form a zygote.

While normal cells contain 46 chromosomes (23 pairs), gamete cells contain only half that number, and it is when these two cells merge into one combined zygote cell that genetic recombination occurs.^{[citation needed]} The zygote then undergoes a defined development process that is known as human embryogenesis, and this starts the typical 38-week gestation period for the embryo (and eventually foetus) that is followed by childbirth.

Assisted reproductive technology also exists, like IVF, some of which involve alternative methods of fertilization, which do not involve sexual intercourse; the fertilization of the ovum may be achieved by artificial insemination methods.

In order for human reproduction to be achieved, an individual must have undergone puberty first, requiring ovulation in females and the spermarche in males to have occurred prior to engaging in sexual intercourse or achieving pregnancy through non-penetrative means. Before puberty, humans are infertile, as their genitals lack reproductive function (only being able to discharge urine).

Legal factors also play a vital role in the achievement of human reproduction: a minor under the age of consent cannot give legal consent to sexual intercourse or artificial alternatives to reproduction, the former case of which is liable to have the older party charged with statutory rape, depending on jurisdictions. Even for minors above the age of consent, comprehensive sex education advises both consenting parties to use contraception to avoid both sexually transmitted infections and early, unplanned/unwanted pregnancies. Pregnancy in girls under the age of 15 is especially discouraged due to their reproductive systems having yet to reach full maturity.

The male reproductive system contains two main divisions: the testicles where sperm are produced, and the penis where semen is ejaculated through the urethra. In humans, both of these organs are outside the abdominal cavity. Having the testicles outside the abdomen facilitates temperature regulation of the sperm, which require specific temperatures to survive about 2-3 °C less than the normal body temperature i.e. 37 °C. In particular, the extraperitoneal location of the testicles may result in a 2-fold reduction in the heat-induced contribution to the spontaneous mutation rate in male germinal tissues compared to tissues at 37 °C. If the testicles remain too close to the body, it is likely that the increase in temperature will harm the spermatozoa formation, making conception more difficult. This is why the testes are carried in an external scrotum rather than within the abdomen; they normally remain slightly cooler than body temperature, facilitating sperm production.

Male germ cells produced in the testes are able to perform special DNA repair processes during meiosis that act to repair DNA damages and to maintain the integrity of the genomes that are to be passed on to progeny. Two of these DNA repair processes are homologous recombinational repair and non-homologous end joining.

The female reproductive system likewise contains two main divisions: the external genitalia (the vulva) and the internal genitalia.