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Hydroxyethyl cellulose
Hydroxyethyl cellulose
Hydroxyethyl cellulose
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Hydroxyethyl cellulose
Names
Other names
Cellulose, hydroxyethyl ether; Hydroxyethylcellulose; 2-Hydroxyethyl cellulose; Hyetellose; Natrosol; Cellosize
Identifiers
ChEBI
ChemSpider
  • none
ECHA InfoCard 100.116.562 Edit this at Wikidata
E number E1525 (additional chemicals)
UNII
Properties
variable
Molar mass variable
Melting point 140 °C (284 °F; 413 K)
Hazards
Safety data sheet (SDS) MSDS
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Hydroxyethyl cellulose is a gelling and thickening agent derived from cellulose. It is widely used in cosmetics, cleaning solutions, and other household products.[1] Hydroxyethyl cellulose and methyl cellulose are frequently used with hydrophobic drugs in capsule formulations, to improve the drugs' dissolution in the gastrointestinal fluids. This process is known as hydrophilization.[2]

Hydroxyethyl cellulose is also used extensively in the oil and gas industry as a drilling mud additive under the name HEC as well in industrial applications, paint and coatings, ceramics, adhesives, emulsion polymerization, inks, construction, welding rods, pencils and joint fillers.

Hydroxyethyl cellulose can be one of the main ingredients in water-based personal lubricants. It is also a key ingredient in the formation of large bubbles as it possesses the ability to dissolve in water but also provide structural strength to the soap bubble. Among other similar chemicals, it is often used as slime (and gunge, in the UK).

Hydroxyethyl cellulose (HEC) is a commonly used thickener in paint & coating formulations. HEC thickeners are used in paint & coating formulations to increase the viscosity of the paint and to improve its flow and leveling properties.[3]

References

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Hydroxyethyl cellulose

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from Grokipedia
Hydroxyethyl cellulose (HEC) is a non-ionic, water-soluble derivative obtained by chemically modifying natural through the addition of hydroxyethyl groups via reaction with . This modification enhances its in while retaining the backbone, resulting in a white, odorless, and tasteless powder with a typical molecular weight ranging from 90,000 to 1,300,000 Da, depending on the degree of substitution (DS) and molar substitution (MS). HEC exhibits versatile rheological properties, including thickening, binding, emulsifying, and stabilizing effects, and it forms viscoelastic solutions that behave as flexible fibers in dilute concentrations (<0.2% w/v), soluble aggregates in semidilute solutions (0.2–1% w/v), and melt-like structures at higher concentrations (>1% w/v). In industrial production, HEC is synthesized from bleached and delignified cellulosic substrates, such as wood pulp, through a two-step process: first, is formed by treating the substrate with under controlled conditions to activate the hydroxyl groups; second, the activated reacts with gaseous in the presence of the to introduce hydroxyethyl linkages, yielding the final product after purification and drying. An alternative single-step method involves treating with high concentrations of (up to 200% w/w) and (>20%) at elevated temperatures (around 100°C) under . HEC finds broad applications across multiple sectors due to its non-toxic, biodegradable nature and low environmental impact. In the pharmaceutical industry, it serves as a viscosity modifier, binder in tablets, controlled-release matrix, and film-coating agent, as well as in ophthalmic solutions like artificial tears. In cosmetics and personal care, it acts as a thickener, stabilizer, and film-former in products such as shampoos, hair conditioners, and lotions, with over 1,360 reported uses. The construction sector employs HEC in cement and mortar formulations for water retention and improved workability, while in paints and coatings, it provides rheological control and pigment dispersion. Additional uses include oil drilling fluids for viscosity enhancement, paper sizing and coating to boost tear strength (up to 14% improvement at 0.5–2% addition), and food processing as a stabilizer (as an indirect additive), with minimal toxicity concerns.

Properties

Chemical structure

Hydroxyethyl cellulose (HEC) is a non-ionic, water-soluble derived from natural by substituting hydroxyl groups on the anhydroglucose units with hydroxyethyl groups through etherification. The general of HEC is [\ceC6H7O2(OH)3−x−m(OCH2CH2OH)x]n\left[ \ce{C6H7O2(OH)3-x-m(OCH2CH2OH)x} \right]_n, where xx represents the degree of molar substitution (MS, typically ranging from 0.5 to 3.0, indicating the average number of hydroxyethyl groups per anhydroglucose unit, including branched chains), mm accounts for the degree of substitution (DS, the number of primary attachments per unit, with MS ≥\geq DS ≤\leq 3), and nn is the (corresponding to the number of anhydroglucose repeating units in the polymer chain). This structure arises from the reaction of alkali-activated with , forming ether linkages (\ce−O−CH2−CH2OH\ce{-O-CH2-CH2OH}) at the available hydroxyl sites on the cellulose backbone, which consists of β\beta-1,4-linked D-glucose units. In a representative structural of the repeating unit, the anhydroglucose ring features three potential substitution sites: primary at the C6 position (exocyclic \ce−CH2OH\ce{-CH2OH}), secondary at C2 and C3 positions (on the ring), and tertiary substitutions occurring via further etherification of the terminal hydroxyl on existing hydroxyethyl chains, leading to branching and higher MS values. The degree of substitution significantly influences the polymer's chain flexibility; higher MS values introduce more hydrophilic hydroxyethyl side chains, disrupting the rigid hydrogen-bonded structure of native and enhancing chain mobility and in aqueous environments.

Physical characteristics

Hydroxyethyl cellulose (HEC) appears as a white to off-white, odorless, free-flowing powder or granules in its pure form. The molecular weight of HEC typically ranges from 90,000 to 1,300,000 Da, with this variation influencing the viscosity of its solutions. Its density is approximately 1.3–1.4 g/cm³, while the falls between 0.3 and 0.6 g/cm³ depending on the grade. Thermally, HEC exhibits a temperature that varies with the degree of substitution, typically around 127°C, and decomposes at approximately 205°C. As a hygroscopic , HEC can absorb up to 5–6% at 50% relative and higher amounts at elevated levels, with packed products containing no more than 5% initial . In commercial grades, varies, with regular grinds passing through U.S. 40 (maximum 10% retained) and finer types like W grind passing through U.S. 80 (maximum 0.5% retained), corresponding to sizes from about 180 to 840 microns.

Solubility and stability

Hydroxyethyl cellulose (HEC) exhibits high solubility in both cold and hot , readily forming clear, viscous solutions without the need for heating or prolonged dispersion times. This solubility arises from its non-ionic nature and the hydrophilic hydroxyethyl substitutions on the backbone, enabling it to hydrate and dissolve across a wide range. In contrast, HEC is insoluble in most organic solvents, including , acetone, and hydrocarbons, though it shows partial solubility in certain polar solvents like acetic acid when mixed with . HEC demonstrates good stability across a broad range of 2 to 12, where solution remains largely unaffected under neutral and alkaline conditions. However, exposure to strong acids below 3 can lead to degradation via of the linkages, reducing molecular weight and over time. Prolonged exposure to high temperatures above 80°C may also cause thermal degradation, particularly in the presence of oxygen or light, though solutions are generally stable to without and changes are reversible upon cooling. Compared to native , HEC shows enhanced resistance to enzymatic attack by cellulases, as the hydroxyethyl substitutions sterically hinder access to the glycosidic bonds along the polymer chain. This biostability is particularly pronounced in neutral to weakly alkaline environments ( 6–8), where activity is optimal but substitution limits . Specialized grades, such as enzyme-resistant (ER) variants, further improve this property for applications requiring long-term microbial stability. In aqueous solutions, HEC displays pseudoplastic (shear-thinning) rheological behavior, where decreases under applied and recovers upon its removal, facilitating easy handling and application. Solution increases with concentration and molecular weight, with higher molecular weight grades producing thicker solutions at equivalent concentrations. This concentration dependence is often modeled by a power-law relationship for the zero-shear : η=k⋅Ca\eta = k \cdot C^{a} where η\eta is the , CC is the concentration, kk is the consistency index, and aa is the flow behavior index (typically 0.5–0.9 for HEC solutions).

Production

Synthesis process

The synthesis of hydroxyethyl cellulose begins with the preparation of alkali cellulose from purified sources, such as wood pulp or linters. The is treated with an aqueous (NaOH) solution, typically 18-30% concentration, to swell the fibers, disrupt hydrogen bonding, and activate the hydroxyl groups by forming ions (sodium cellulosate). This step occurs at low temperatures, around 0-20°C, for several hours to ensure uniform without excessive degradation. The activated alkali cellulose is then slurried in or an organic and reacted with (EO) gas under pressurized conditions in a heterogeneous process. The reaction proceeds via nucleophilic attack by the cellulose on the less substituted (terminal) carbon of the EO ring, leading to ring-opening and formation of a β-hydroxyethoxy anion intermediate. This anion is subsequently protonated by or residual , yielding the hydroxyethyl linkage (Cell-O-CH₂-CH₂-OH). The process is typically conducted at 30-50°C to balance reaction rate and selectivity, with the alkoxide concentration and EO addition rate controlled to achieve desired substitution levels. Further substitution can occur on the new terminal hydroxyl group, extending chains in a polyoxyethylenation manner. The degree of substitution (DS) is defined as the average number of hydroxyl groups per anhydroglucose unit (AGU) replaced by hydroxyethyl groups, targeted in the range of 0.1-4.0 for various applications, while molar substitution (MS) accounts for the total moles of EO incorporated per AGU, often exceeding DS due to chain extension (e.g., MS up to 6.0). DS and MS are precisely controlled by adjusting the EO-to-cellulose molar ratio (e.g., 1-10 moles EO per AGU), concentration (15-40% NaOH), reaction time (1-6 hours), and temperature; higher EO and favor greater substitution, but excess can lead to uneven distribution across C2, C3, and C6 positions of the AGU. Side reactions, such as the formation of polyethylene glycols via EO homopolymerization or reaction with water to produce ethylene glycol and its ethers, are minimized by maintaining temperatures below 50-60°C, limiting water content (6-10 wt%), and using staged EO addition to prevent localized high concentrations. These byproducts can reduce yield and purity if unchecked. Following the reaction, the crude product is neutralized with a dilute acid, such as acetic or hydrochloric acid, to quench excess alkali and form the neutral hydroxyethyl cellulose. It is then washed multiple times with water, methanol, or aqueous alcohol solutions to remove sodium salts, unreacted EO, and soluble byproducts like glycols. The purified material is finally dried at 40-60°C under vacuum or air to yield a white, free-flowing powder.

Commercial manufacturing

Hydroxyethyl cellulose (HEC) was first commercialized in the United States in 1937–1938, marking the beginning of industrial-scale production from alkali cellulose reacted with ethylene oxide. Major producers include Dow Chemical Company, which markets HEC under the Cellosize™ brand, Ashland Global Holdings Inc. under the Natrosol™ brand, and Shin-Etsu Chemical Co., Ltd. under the Tylose® brand, with these companies dominating global supply since the mid-20th century. Commercial manufacturing typically employs slurry reactor processes, often in batch mode, where cellulose is suspended in an aqueous or organic medium under a atmosphere to prevent unwanted of (EO). The inerting, achieved by evacuating the and introducing multiple times, minimizes oxidation and ensures safe handling of the reactive EO gas. Continuous processes are less common but used by some producers for higher-volume grades to improve efficiency. Process variations include one-step direct , where alkalization and etherification occur simultaneously in a single reactor, and two-step methods involving pre-swelling of with to form alkali cellulose before EO addition, allowing better control over substitution levels. The two-step approach is preferred for producing higher-viscosity grades, as it enables uniform distribution of hydroxyethyl groups and reduces side reactions. Quality control focuses on specifying viscosity grades based on 2% aqueous solutions, ranging from low-viscosity types (5–50 cP) for applications to ultra-high-viscosity grades (>100,000 cP) for thick gels, with molecular weight and molar substitution (typically 1.5–3.0) tightly monitored via Brookfield viscometry and . Energy management involves heat recovery from exothermic etherification reactions, while waste streams—primarily sodium salts and unreacted EO—are handled through effluent neutralization and for EO recovery to minimize emissions and comply with regulations. Global production capacity is estimated at 150,000 tons annually in the mid-2020s, driven primarily by in personal care formulations.

Applications

Industrial uses

Hydroxyethyl cellulose (HEC) serves as a versatile additive in various , particularly in and , where its non-ionic, water-soluble nature enables effective thickening, stabilization, and water retention. In paints, coatings, and adhesives, HEC functions as a thickener and modifier, providing sag resistance, improved leveling, and enhanced film formation in waterborne systems. Typical addition levels range from 0.2% to 1.0% based on the , allowing for better control and reduced sagging during application. For instance, in paints, it stabilizes emulsions and improves brushability without compromising flow. In adhesives, such as nonwoven binders, HEC at 0.2–0.5% enhances tack and water release properties. Within cement and mortar production, HEC acts as a water retention agent, typically added at 0.1–0.5% by weight of the dry mix, to prevent premature drying and cracking while enhancing workability and . This addition promotes uniform hydration of particles, increasing water retention capacity and workability, though it may prolong setting times and reduce early-stage mechanical strength with minimal impact on late-stage strength. In the oil and gas sector, HEC is employed as a viscosifier in fluids, where it suspends cuttings and maintains stability even under high-salinity conditions. Its pseudoplastic allows for efficient fluid flow during pumping while providing suspension at rest, and it remains effective in brines and fracturing fluids. HEC's stability in saline environments makes it suitable for workover and completion operations, with typical use in low-solids systems to minimize formation damage. For paper and textile sizing, HEC serves as a binder that strengthens fibers and improves surface properties without introducing excessive . In paper production, additions of 0.1–0.5 pounds per 1,000 square feet enhance gloss, ink holdout, and tensile strength. In textiles, it acts as a warp sizing agent at 0.2–0.5%, protecting yarns during and allowing easy removal by aqueous washing post-processing. These applications leverage HEC's film-forming ability to boost product quality and process efficiency. HEC also finds use in ceramic glazes as a suspension aid for pigments and particles, preventing settling and ensuring uniform application. By maintaining dispersion in slurry formulations, it reduces defects in fired glazes and supports consistent pigment distribution during storage and dipping processes. This role as a green strength binder further aids in handling ceramic powders before sintering. In 2024, paints and coatings applications accounted for approximately 42% of the global HEC market, driven by demand for waterborne formulations and growth.

Consumer and pharmaceutical products

Hydroxyethyl cellulose (HEC) serves as a versatile thickener and stabilizer in and , where it is typically incorporated at concentrations of 0.5–2% to enhance texture, improve stability, and provide a smooth sensory feel. In shampoos and conditioners, it acts as a modifier to control and foam stability, while in lotions and creams, it functions as an stabilizer and film former to prevent and ensure even application. formulations benefit from HEC's binding properties, which contribute to a consistent paste consistency without altering the product's flavor or color. In the , HEC is approved as the additive E1525 and functions primarily as a thickener and suspension agent. It is employed in sauces and dressings to maintain uniform consistency and prevent ingredient settling, and in to stabilize emulsions and improve during storage and serving. Regulatory bodies such as the FDA affirm HEC as (GRAS) for direct use in foods as a stabilizer and thickener under good manufacturing practices, with no specified maximum level beyond purity standards in the . HEC plays a critical role as an in pharmaceutical products, where it enhances performance through its non-ionic, water-soluble nature. As a binder in tablet , it promotes cohesion during compression, ensuring tablet without affecting drug release profiles. In , HEC increases to provide and prolong contact time on the ocular surface, alleviating dryness and irritation in conditions like . It also forms controlled-release matrices in oral by swelling in aqueous environments to modulate drug . Specific applications include solutions, where HEC improves mucoadhesion for better lens comfort and wettability, and oral suspensions, where it disperses active ingredients evenly and prevents sedimentation. In topical gels, HEC is used at typical concentrations of 0.1–1% to achieve sustained release and bioadhesive properties. The FDA recognizes HEC as safe for pharmaceutical use, and in the , it complies with cosmetic safety assessments under Regulation (EC) No 1223/2009 for rinse-off and leave-on products.

Safety and regulation

Health effects

Hydroxyethyl cellulose exhibits low , with an oral LD50 greater than 5,000 mg/kg in rats, indicating minimal risk from single high-dose ingestion. It is non- to and eyes at typical concentrations used in products, as demonstrated in studies where ocular irritation cleared within 24 hours and dermal exposure produced no adverse effects. The compound shows no evidence of or carcinogenicity based on assessments of related derivatives using guidelines, with non-mutagenic results in bacterial assays. Hydroxyethyl cellulose is inert in the and not systemically absorbed, with over 96% excreted unchanged in in rat studies. Allergic reactions are rare but possible in sensitive individuals, primarily due to residual from synthesis, which is limited to below 1 ppm in food-grade specifications to minimize risk. Occupational exposure to dust may cause mild respiratory , with a (TLV) established at 10 mg/m³ for inhalable nuisance dust. Chronic toxicity studies in rats fed up to 5% dietary levels for 90 days showed no adverse effects on growth, organ function, or . Similarly, no reproductive or developmental effects were observed in animal models at these concentrations. Its is confirmed by safe use in medical applications, such as ophthalmic formulations for and solutions, where it provides viscosity without causing irritation. is (GRAS) by the U.S. (FDA) for use as a direct at levels not exceeding (21 CFR 172.868) and is authorized in the as a food additive under E 1525.

Environmental considerations

Hydroxyethyl cellulose (HEC) exhibits slow biodegradability under aerobic conditions, with studies showing approximately 37% degradation after 61 days in inherent biodegradability tests ( 302B), though it does not meet the criteria for ready biodegradability in standard 28-day assays ( 301 series, typically <60% required for classification). This rate is improved compared to native cellulose, which is largely non-biodegradable in aqueous environments due to its insolubility, as the etherification enhances water solubility and microbial accessibility. Ecotoxicity of HEC is low toward aquatic organisms, with no acute toxicity expected (EC50/LC50 >100 mg/L for , , and based on similar cellulosic polymers). It shows no potential for , evidenced by a calculated log Kow of -7.52, well below the threshold of 3 for concern. Production of HEC involves reacting alkali cellulose with , a (VOC) and known , leading to potential emissions during etherification; however, modern facilities employ closed-loop systems and achieve at least 99% reduction in hazardous air pollutant emissions as regulated under U.S. EPA standards for cellulose products . The process starts with a renewable base of derived from wood pulp or linters, but the etherification step is energy-intensive, contributing to a life-cycle comparable to other modified cellulosics. HEC is classified as non-hazardous , facilitating straightforward disposal; however, production , generated from neutralization and purification steps, contains salts such as and requires treatment via or to prevent environmental discharge impacts. In the , sustainability efforts in HEC production include a shift toward bio-based sourced from renewable feedstocks like , with commercial-scale facilities operational since 2017 and expanded by companies like Croda and using certification for bio-attributed products. Additionally, recyclable HEC grades are increasingly formulated for eco-friendly applications in personal care and , reducing reliance on virgin materials.

References

  1. https://pubchem.ncbi.nlm.nih.gov/compound/Hydroxyethyl-cellulose
  2. https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/hydroxyethyl-cellulose
  3. https://pmc.ncbi.nlm.nih.gov/articles/PMC9657194/
  4. https://www.ashland.com/file_source/Ashland/links/PHA18-101_Natrosol_250_HEC_Formulating_elegant_liquid_and_semisolid_%20drug_products.pdf
  5. https://rucore.libraries.rutgers.edu/rutgers-lib/74044/PDF/1/play/
  6. https://cms.chempoint.com/ic/IndustrialCellulosics/media/IndustrialCellulosics/CELLOSIZE-Technical-Handbook.pdf
  7. https://chemistryconnection.com/sds/data/pdf/Technical_Data_Natrosol_HEC_%28including_250HHR%29.pdf
  8. https://www.chemicalbook.com/ChemicalProductProperty_EN_CB6356167.htm
  9. https://www.sciencedirect.com/science/article/abs/pii/S0378517315303975
  10. https://cms.chempoint.com/ic/IndustrialCellulosics/media/IndustrialCellulosics/CELLOSIZE-Technical-Handbook.pdf?ext=.pdf
  11. https://pmc.ncbi.nlm.nih.gov/articles/PMC7587591/
  12. https://www.sciencedirect.com/science/article/abs/pii/S0022354915354034
  13. https://www.sciencedirect.com/science/article/abs/pii/S0964830511001715
  14. https://www.kdochem.com/news/what-factors-are-related-to-the-enzyme-resistance-of-hechydroxyethyl-cellulose.html
  15. https://pubs.aip.org/sor/jor/article/20/4/639/417601/The-Rheology-of-Hydroxyethyl-Cellulose-Solutions
  16. https://iopscience.iop.org/article/10.1088/1742-6596/1045/1/012008/pdf
  17. https://www.sciencedirect.com/science/article/pii/S2468203917303710
  18. https://onlinelibrary.wiley.com/doi/10.1155/2013/650837
  19. https://patents.google.com/patent/US4084060A/en
  20. https://celluloseether.com/history-of-production-and-research-of-cellulose-ethers/
  21. https://www.dow.com/en-us/market/mkt-beauty-personal-care/cellosize-hec-thickeners.html
  22. https://www.ashland.com/industries/personal-and-home-care/oral-care/natrosol-hydroxyethylcellulose
  23. https://www.shinetsu.co.jp/en/products/functional-materials/metolose-for-personal-care-tylose-for-personal-care/
  24. https://www.cellulosechina.com/hydroxyethyl-cellulose-production-process/
  25. https://patents.google.com/patent/CN101250230A/en
  26. https://www.kimachemical.com/news/how-to-make-cellulose-ether/
  27. https://patents.google.com/patent/DE2751411C2/en
  28. https://www.epa.gov/sites/default/files/2020-07/documents/cellulose_eia_neshap_proposal_05-2000.pdf
  29. https://www.reportsanddata.com/report-detail/hydroxyethyl-cellulose-market
  30. https://www.dow.com/en-us/pdp.cellosize-qp-4400h-hydroxyethyl-cellulose.129123z.html
  31. https://www.polysciences.com/products/cellulose-hydroxyethyl-ether-mw-90000
  32. https://www.researchgate.net/publication/318092948_Effect_of_non-ionic_cellulose_ethers_on_properties_of_white_Portland_cement
  33. https://www.sciencedirect.com/science/article/abs/pii/S0008884612000695
  34. https://pmc.ncbi.nlm.nih.gov/articles/PMC7372461/
  35. https://glossary.slb.com/terms/h/hec
  36. https://www.cpchem.com/what-we-do/solutions/drilling-specialties/products/liquid-hec-polymer
  37. https://www.oil-drilling-fluids.com/viscosifiers-hydroxy-ethyl-cellulose
  38. https://www.celotech.com/news/application-of-hydroxyethyl-cellulose-hec/
  39. https://patents.google.com/patent/US2736653A/en
  40. https://www.yibangchemical.com/news/hydroxyethyl-cellulose-hec-in-ceramic-glazes/
  41. https://www.emergenresearch.com/industry-report/hydroxyethyl-cellulose-market
  42. https://www.accessdata.fda.gov/drugsatfda_docs/nda/2019/212279Orig1s000MultidisciplineR.pdf
  43. https://www.food-info.net/uk/e/e1525.htm
  44. https://eatoravoid.com/additive/hydroxyethyl-cellulose-e1525/
  45. https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=172.868
  46. https://pmc.ncbi.nlm.nih.gov/articles/PMC9609046/
  47. https://pubmed.ncbi.nlm.nih.gov/37301242/
  48. https://www.sciencedirect.com/topics/nursing-and-health-professions/hydroxyethylcellulose
  49. https://www.chempoint.com/products/download?grade=44729&doctype=sds
  50. https://cir-reports.cir-safety.org/view-attachment?id=2e65c18f-8c74-ec11-8943-0022482f06a6
  51. https://redox.com/wp-content/sds/1029.pdf
  52. https://ec.europa.eu/food/food-feed-portal/screen/food-additives/412?flt-additives_sci_name_s=hydroxyethyl%20cellulose
  53. https://www.chempoint.com/products/download?grade=44734&doctype=sds
  54. https://www.sciencedirect.com/science/article/pii/S0045653524001917
  55. https://www.regulations.gov/document/EPA-HQ-OAR-2018-0415-0001
  56. https://apps.carboncloud.com/climatehub/product-reports/id/1267952392638
  57. https://patents.google.com/patent/US3347847A/en
  58. https://www.ieabioenergy.com/wp-content/uploads/2020/02/Bio-based-chemicals-a-2020-update-final-200213.pdf
  59. https://www.indianchemicalnews.com/chemical/ineos-launches-new-bio-attributed-ethylene-oxide-14245
  60. https://www.setylose.com/en/sustainability/assessment
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