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ICAM5
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| ICAM5 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | ICAM5, TLCN, TLN, intercellular adhesion molecule 5 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 601852; MGI: 109430; HomoloGene: 2447; GeneCards: ICAM5; OMA:ICAM5 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Intercellular adhesion molecule 5 is a protein that in humans is encoded by the ICAM5 gene.[5][6][7]
The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is expressed on the surface of telencephalic neurons and displays two types of adhesion activity, homophilic binding between neurons and heterophilic binding between neurons and leukocytes. It may be a critical component in neuron-microglial cell interactions in the course of normal development or as part of neurodegenerative diseases.[7]
Studies mentioned a role for ICAM5 in cell adhesion and cell signalling and dysregulation and disfunction of it will increase the risk of breast cancer.[8] Study of the association between polymorphisms and breast cancer has been shown that ICAM5 rs1056538 and ICAM5 rs281439 variants might contribute the most in the development of breast cancer.[9]
Interactions
[edit]References
[edit]- ^ a b c GRCh38: Ensembl release 89: ENSG00000105376 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032174 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Mizuno T, Yoshihara Y, Inazawa J, Kagamiyama H, Mori K (Feb 1997). "cDNA cloning and chromosomal localization of the human telencephalin and its distinctive interaction with lymphocyte function-associated antigen-1". J Biol Chem. 272 (2): 1156–63. doi:10.1074/jbc.272.2.1156. PMID 8995416.
- ^ Kilgannon P, Turner T, Meyer J, Wisdom W, Gallatin WM (Jan 1999). "Mapping of the ICAM-5 (telencephalin) gene, a neuronal member of the ICAM family, to a location between ICAM-1 and ICAM-3 on human chromosome 19p13.2". Genomics. 54 (2): 328–30. doi:10.1006/geno.1998.5565. PMID 9828136.
- ^ a b "Entrez Gene: ICAM5 intercellular adhesion molecule 5, telencephalin".
- ^ Kammerer, Stefan; Roth, Richard B.; Reneland, Richard; Marnellos, George; Hoyal, Carolyn R.; Markward, Nathan J.; Ebner, Florian; Kiechle, Marion; Schwarz-Boeger, Ulrike; Griffiths, Lyn R.; Ulbrich, Christian; Chrobok, Korbinian; Forster, Gerhard; Praetorius, Georg M.; Meyer, Peter (2004-12-16). "Large-Scale Association Study Identifies ICAM Gene Region as Breast and Prostate Cancer Susceptibility Locus". Cancer Research. 64 (24): 8906–8910. doi:10.1158/0008-5472.CAN-04-1788. ISSN 0008-5472. PMID 15604251.
- ^ Liu, Lin; Sun, Meili; Song, Degang; Wang, Zhehai (2013-02-01). "The genetic polymorphisms of intercellular cell adhesion molecules and breast cancer susceptibility: a meta-analysis". Molecular Biology Reports. 40 (2): 1855–1860. doi:10.1007/s11033-012-2241-4. ISSN 1573-4978. PMID 23079714.
- ^ Annaert, W G; Esselens C; Baert V; Boeve C; Snellings G; Cupers P; Craessaerts K; De Strooper B (Nov 2001). "Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins". Neuron. 32 (4): 579–89. doi:10.1016/S0896-6273(01)00512-8. ISSN 0896-6273. PMID 11719200. S2CID 2096602.
Further reading
[edit]- Yoshihara Y, Mori K (1995). "Telencephalin: a neuronal area code molecule?". Neurosci. Res. 21 (2): 119–24. doi:10.1016/0168-0102(94)90153-8. PMID 7724062. S2CID 19931440.
- Hayflick JS, Kilgannon P, Gallatin WM (1998). "The intercellular adhesion molecule (ICAM) family of proteins. New members and novel functions". Immunol. Res. 17 (3): 313–27. doi:10.1007/BF02786454. PMID 9638475. S2CID 19901365.
- Benson DL, Yoshihara Y, Mori K (1998). "Polarized distribution and cell type-specific localization of telencephalin, an intercellular adhesion molecule". J. Neurosci. Res. 52 (1): 43–53. doi:10.1002/(SICI)1097-4547(19980401)52:1<43::AID-JNR5>3.0.CO;2-K. PMID 9556028. S2CID 22675478.
- Rieckmann P, Turner T, Kligannon P, Steinhoff BJ (1998). "Telencephalin as an indicator for temporal-lobe dysfunction". Lancet. 352 (9125): 370–1. doi:10.1016/S0140-6736(05)60469-2. PMID 9717930. S2CID 6255738.
- Arii N, Mizuguchi M, Mori K, Takashima S (1999). "Development of telencephalin in the human cerebrum". Microsc. Res. Tech. 46 (1): 18–23. doi:10.1002/(SICI)1097-0029(19990701)46:1<18::AID-JEMT2>3.0.CO;2-G. PMID 10402269. S2CID 22133468.
- Mizuno T, Yoshihara Y, Kagamiyama H, et al. (2000). "Neuronal adhesion molecule telencephalin induces rapid cell spreading of microglia". Brain Res. 849 (1–2): 58–66. doi:10.1016/S0006-8993(99)01984-8. PMID 10592287. S2CID 353053.
- Tian L, Kilgannon P, Yoshihara Y, et al. (2000). "Binding of T lymphocytes to hippocampal neurons through ICAM-5 (telencephalin) and characterization of its interaction with the leukocyte integrin CD11a/CD18". Eur. J. Immunol. 30 (3): 810–8. doi:10.1002/1521-4141(200003)30:3<810::AID-IMMU810>3.0.CO;2-X. PMID 10741396.
- Tian L, Nyman H, Kilgannon P, et al. (2000). "Intercellular adhesion molecule-5 induces dendritic outgrowth by homophilic adhesion". J. Cell Biol. 150 (1): 243–52. doi:10.1083/jcb.150.1.243. PMC 2185561. PMID 10893271.
- Annaert WG, Esselens C, Baert V, et al. (2002). "Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins". Neuron. 32 (4): 579–89. doi:10.1016/S0896-6273(01)00512-8. PMID 11719200. S2CID 2096602.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
- Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. Bibcode:2004AnaCh..76.2763B. doi:10.1021/ac035352d. PMID 15144186.
- Cox DG, Hankinson SE, Hunter DJ (2006). "Polymorphisms in the ICAM gene locus are not associated with breast cancer Risk". Cancer Epidemiol. Biomarkers Prev. 15 (1): 178–9. doi:10.1158/1055-9965.EPI-05-0790. PMID 16434609.
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