Infestation 2 (stylized in some solicitations as Infes2ation) is a comic book crossover that was published by IDW Publishing from January to April 2012. Serving as the sequel to Infestation, it consisted of two book-end one-shots, and two-issue limited series from The Transformers, Dungeons & Dragons, Teenage Mutant Ninja Turtles, G.I. Joe and 30 Days of Night.

A new threat emerges as Great Old Ones (based on the work of H. P. Lovecraft) break free from their cosmic prison and invade the universes of CVO: Covert Vampiric Operations, The Transformers: Hearts of Steel, Dungeons & Dragons, Teenage Mutant Ninja Turtles, G.I. Joe and 30 Days of Night, affecting the fabric of reality.

Published from January to April 2012. Written by Duane Swierczynski with art by David Messina.

Published biweekly in February 2012. Written by Chuck Dixon with art by Guido Guidi. The series is not a direct sequel to The Transformers: Infestation and takes place in the universe of The Transformers: Hearts of Steel.

Published biweekly in February 2012. Written by Paul Crilley with art by Valerio Schiti.

Published in February 2012. Written by Chris Ryall with art by Alan Robinson. It is a humorous take on the event and features Archie from Groom Lake and Bat Boy from Weekly World News.

Published biweekly in March 2012. Written by Tristan Jones with art by Mark Torres.

Published biweekly in March 2012. Written by Mike Raicht with art by Valentine de Landro.