Interstate 375 (I-375) is a north–south auxiliary Interstate Highway in Detroit, Michigan, United States. It is the southernmost leg of the Walter P. Chrysler Freeway and a spur of I-75 into Downtown Detroit, ending at the unsigned Business Spur I-375 (BS I-375), better known as Jefferson Avenue. The freeway opened on June 12, 1964. At only 1.062 miles (1.709 km) in length, it once had the distinction of being the shortest signed Interstate Highway in the country before I-110 in El Paso, Texas, was signed. The Michigan Department of Transportation (MDOT) announced in 2021 plans to convert the freeway to a boulevard. Details of that project were revealed in April 2023 with MDOT reaffirming that construction is scheduled to begin in 2025.

I-375 and the Chrysler Freeway begin at Jefferson Avenue between St. Antoine Street and Beaubien Street in Downtown Detroit near the Renaissance Center. The freeway runs east before turning north. Just about a mile (1.6 km) after the southern terminus, I-375 meets the Fisher Freeway which carries I-75 north of downtown. At this interchange, I-75 takes ramps to leave the Fisher Freeway and uses the Chrysler Freeway, replacing I-375. I-375 is a four-lane freeway south of the I-75 interchange, where it widens to six lanes. As with all other Interstate Highways, the entire length of I-375 is included on the National Highway System, a network of roadways that are important to the country's economy, defense, and mobility.

According to MDOT, I-375 is 1.062 miles (1.709 km). At the time it opened until at least 2007, I-375 was the shortest signed Interstate in the country. Based on Federal Highway Administration (FHWA) data, there are three Interstates that are shorter: I-110 in Texas (0.92 mi or 1.48 km), I-878 in New York (0.70 mi or 1.13 km), and I-315 in Montana (0.83 mi or 1.34 km). The latter two designations are not signed on their respective roadways, and I-110 in Texas has since been signed.

Every year, MDOT conducts a series of surveys on its highways in the state to measure traffic volume. In 2009, MDOT calculated that 14,112 vehicles per day used the southernmost section of I-375 on average and 53,900 vehicles used the northernmost section near I-75. These vehicles included 798 trucks.

Construction on the first segments of the Chrysler Freeway started on January 30, 1959. The area where the freeway was built was called Black Bottom, a historic district that received its name from the soil found there by French explorers. In the 1940s and 1950s, the area was home to a community of African-American entrepreneurs and businesses that rivaled Harlem in New York City. Black Bottom was one of the oldest neighborhoods in the city, and, at the time of freeway construction, it had wooden sewers and dilapidated buildings.

In the 1950s and 1960s, the neighborhood was one of the poorest in the city. There was a perception among whites that the duplexes its residents lived in were overcrowded and run-down, putting the neighborhood in the crosshairs of the 1960s policies of slum clearance. The area, like Corktown to the west of downtown, was targeted by urban planners for demolition in the 1950s and 1960s, which included the Chrysler Freeway and public housing projects.

In the case of the construction of the Chrysler Freeway, some of the most crucial entertainment and cultural communities in Detroit, Black Bottom, and Paradise Valley were destroyed. The unrest this caused is sometimes cited as a contributing factor to the 1967 Detroit riot.

On June 12, 1964, a surface street highway/freeway in Detroit that ran north from Jefferson Avenue and Randolph Street to the Fisher/Chrysler freeway interchange was opened. The southernmost segment, built through the Black Bottom neighborhood, was designated I-375 at this time. The freeway cost $50 million to build (equivalent to $385 million in 2024).