The Iowa State Cyclones men's wrestling team represents Iowa State University (ISU) and competes in the Big 12 Conference of NCAA Division I. The Cyclones are 8-time national champions, 17 time National Runners-Up, and have 45 Trophy Finishes. The team is coached by Kevin Dresser. The Cyclones host their home meets at Hilton Coliseum on Iowa State's campus. Iowa State became the second collegiate wrestling program to reach 1,100 dual wins on January 23, 2022.

Iowa State will add women's wrestling as a varsity sport in the 2027–28 school year.

Charles Mayser was the founding father of Iowa State wrestling. In addition to his wrestling coaching duties, “Uncle Charlie” performed coaching duties in baseball and football, as well as being the athletic director. Mayser joined the athletic staff in 1916, the initial season of Cyclone wrestling. He coached for eight years and was responsible for five undefeated teams during his tenure. Despite lack of equipment and facilities, Mayser's squads dominated the Midwestern wrestling scene. His teams suffered only two defeats in his last six years and his last two squads were named unofficial national champions by Amateur Wrestling News. Mayser left Iowa State in 1923 to head the Franklin & Marshall College athletic department.

During his eight years at Iowa State, Mayser went 35–4 during including one conference championship.

Hugo Otopalik took over head coaching duties after serving as an assistant on Charles Mayser's staff for four years. In his 28 years as head coach, Otopalik's teams claimed seven conference championships and one NCAA title. He ended his illustrious career with a 159-66-5 mark and eight NCAA individual champions. Besides having a huge impact on Iowa State athletics, Otopalik also made his mark on the international scene. In 1932, Otopalik served as head coach of the U.S. Olympic squad, which captured the team title at the Los Angeles Games. He also headed the National AAU Wrestling Committee for five years.

During his 29 years at Iowa State, Otopalik went 159-65-6 including four conference championships and one NCAA championship.

When you talk Iowa State wrestling history, Harold Nichols looms large. From 1965 to 1973, Nichols’ squads were the most dominant in wrestling, compiling five NCAA titles and three runner-up finishes. Nichols was named the successor to Hugo Otopalik in 1954 after serving as head coach at Arkansas State for five years. His ISU teams racked up six NCAA titles, seven Big Eight titles and produced 38 NCAA individual champions and 91 Big Eight titlists. His career record at Iowa State is an untouchable 456-75-11. Nichols was named coach of the year three times and was tabbed Wrestling Man of the Year by Amateur Wrestling News in 1966. He is a member of the Helms Foundation Wrestling Hall of Fame, Iowa Wrestling Hall of Fame, National Wrestling Hall of Fame and served as vice-chairman of the United States Olympic Wrestling Committee. Nichols retired from coaching in 1985.

During his 31 years at Iowa State, Dr. Nichols went 456-75-11 including seven conference championships and six NCAA championships.