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Isepamicin
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Isepamicin
Isepamicin (isepamycin) is an aminoglycoside antibiotic.
It was patented in 1973 and approved for medical use in 1988. It has been identified by the World Health Organization as a Critically Important Antimicrobial for human use.
Isepamicin can be synthesized by derivatization of gentamicin B (1) with benzyl N-[(2S)-3-(2,5-dioxopyrrolidin-1-yl)-2-hydroxy-3-oxopropyl]carbamate (2), followed by deprotection.
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Isepamicin
Isepamicin (isepamycin) is an aminoglycoside antibiotic.
It was patented in 1973 and approved for medical use in 1988. It has been identified by the World Health Organization as a Critically Important Antimicrobial for human use.
Isepamicin can be synthesized by derivatization of gentamicin B (1) with benzyl N-[(2S)-3-(2,5-dioxopyrrolidin-1-yl)-2-hydroxy-3-oxopropyl]carbamate (2), followed by deprotection.
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