Isetan (伊勢丹, Isetan) (TYO: 8238 unlisted on March 26, 2008, SGX: I15 ) is a Japanese department store. Based in Shinjuku, Tokyo, Isetan has branches throughout Japan and South East Asia, including in Jinan, Kuala Lumpur, Selangor, Shanghai, Singapore, and Tianjin, and formerly in Bangkok, Hong Kong, Kaohsiung, London, and Vienna.

On April 1, 2008, Isetan and Mitsukoshi were merged under a joint holding company called Isetan Mitsukoshi Holdings Ltd. (TYO: 3099).

*at current exchange rate **joint venture with

Isetan's first Malaysian outlet at the Weld Complex opened in late 1988.

Isetan operates as a sublessor in Singapore at Orchard's Wisma Atria, where it was previously opened, but closed in March 2015, and subsequently converted for rental purposes. Currently the space, leased to Isetan, is filled with Mango, iora, Salon Vim, DRx Medical Aesthetic Clinic, YANN VEYRIE SALON, Franck Muller, Gautier Stylish French Living, Longines, World of Watches, UCHINO MYMY, SCANTEAK, and Sony.

Several stores were closed down due to COVID-19 pandemic. These include Westgate, of which it was closed down on 8 March 2020 (replaced by Love Bonito and Scarlett), followed by CentralWorld store at Bangkok while restaurant zone and Kinokuniya Bookstores will still remain., and the closure of Parkway Parade branch on 31 January 2022 (replaced by HOOGA, Muji and Canton Paradise), and also the closure of 1 Utama branch on 5 April 2022. Also the Japan Food Town, the cluster of Japanese restaurants on the fourth floor of what previously known as Isetan Wisma Atria was shuttered. Prior to closure, some tenants were already moved out. Isetan has already received offers from external parties interested to lease its space.

Isetan Tampines officially closed down on 30 October 2025. It will be followed by its NEX Serangoon branch in April 2026.